Cox analysis of variables predicting progression to dialysis in the testing cohort (Italian cohort, n = 461)
| Variable . | HR (95% CI) . | P . |
|---|---|---|
| Univariate analysis | ||
| Age, y | 1.00 (0.98-1.03) | .879 |
| Male gender | 0.73 (0.46-1.16) | .190 |
| Heart involvement | 1.07 (0.65-1.73) | .779 |
| Cardiac stage III | 1.21 (0.69-2.15) | .505 |
| Liver involvement | 1.11 (0.60-2.07) | .737 |
| Proteinuria, g/24 h | 1.11 (1.07-1.15) | <.001 |
| Proteinuria >5 g/24 h | 3.67 (2.05-6.57) | <.001 |
| eGFR, mL/min per 1.73m2 | 0.96 (0.95-0.97) | <.001 |
| eGFR <50 mL/min per 1.73 m2 | 6.96 (4.15-11.68) | <.001 |
| Serum albumin, g/L | 0.44 (0.29-0.79) | .025 |
| Serum albumin <30 g/L | 4.20 (0.91-19.29) | .067 |
| dFLC | 1.00 (0.99-1.01) | .846 |
| dFLC >160 ng/L | 1.00 (0.62-1.62) | .999 |
| Multivariate model including continuous variables | ||
| Proteinuria, g/24 h | 1.08 (1.03-1.12) | <.001 |
| eGFR, mL/min per 1.73 m2 | 0.96 (0.95-0.97) | <.001 |
| Serum albumin, g/L | 1.52 (0.64-6.85) | .186 |
| Multivariate model including dichotomous variables | ||
| Proteinuria >5 g/24 h | 3.91 (2.18-7.00) | <.001 |
| eGFR <50 mL/min per 1.73 m2 | 7.24 (4.31-12.15) | <.001 |
| Serum albumin <30 g/L | 1.37 (0.74-8.56) | .214 |
| Variable . | HR (95% CI) . | P . |
|---|---|---|
| Univariate analysis | ||
| Age, y | 1.00 (0.98-1.03) | .879 |
| Male gender | 0.73 (0.46-1.16) | .190 |
| Heart involvement | 1.07 (0.65-1.73) | .779 |
| Cardiac stage III | 1.21 (0.69-2.15) | .505 |
| Liver involvement | 1.11 (0.60-2.07) | .737 |
| Proteinuria, g/24 h | 1.11 (1.07-1.15) | <.001 |
| Proteinuria >5 g/24 h | 3.67 (2.05-6.57) | <.001 |
| eGFR, mL/min per 1.73m2 | 0.96 (0.95-0.97) | <.001 |
| eGFR <50 mL/min per 1.73 m2 | 6.96 (4.15-11.68) | <.001 |
| Serum albumin, g/L | 0.44 (0.29-0.79) | .025 |
| Serum albumin <30 g/L | 4.20 (0.91-19.29) | .067 |
| dFLC | 1.00 (0.99-1.01) | .846 |
| dFLC >160 ng/L | 1.00 (0.62-1.62) | .999 |
| Multivariate model including continuous variables | ||
| Proteinuria, g/24 h | 1.08 (1.03-1.12) | <.001 |
| eGFR, mL/min per 1.73 m2 | 0.96 (0.95-0.97) | <.001 |
| Serum albumin, g/L | 1.52 (0.64-6.85) | .186 |
| Multivariate model including dichotomous variables | ||
| Proteinuria >5 g/24 h | 3.91 (2.18-7.00) | <.001 |
| eGFR <50 mL/min per 1.73 m2 | 7.24 (4.31-12.15) | <.001 |
| Serum albumin <30 g/L | 1.37 (0.74-8.56) | .214 |
dFLC, difference between involved (amyloidogenic) and uninvolved free light chain.