Amino acid residues of TP53 affected by mutations
| Site of respective mutation . | Number of patients with respective mutation . |
|---|---|
| Arg273* | 9 |
| Arg175*, Arg282* | 7 |
| Arg248*, Ile195 | 5 |
| Arg283 | 4 |
| Tyr220, Tyr234, Met237, Gly245*, Ile332 | 3 |
| Ser127, Lys132, Arg158, Cys176, Leu194, Val216, Cys238, Ser241, Cys242, Gly244, Cys275, Glu285, Arg337 | 2 |
| Trp53, Arg72, Pro128, Met133, Cys135, Gln136, Cys141, Val143, Thr150, Pro151, Lys164, Gly199, Tyr205, Arg213, Tyr236, Met246, Arg267, Phe270, Val272, Ala276, Pro278, Gly279, Asp281, Thr284, Glu286, Arg290, Lys292, Ile331, Glu349, Met384, Phe385 | 1 each |
| Site of respective mutation . | Number of patients with respective mutation . |
|---|---|
| Arg273* | 9 |
| Arg175*, Arg282* | 7 |
| Arg248*, Ile195 | 5 |
| Arg283 | 4 |
| Tyr220, Tyr234, Met237, Gly245*, Ile332 | 3 |
| Ser127, Lys132, Arg158, Cys176, Leu194, Val216, Cys238, Ser241, Cys242, Gly244, Cys275, Glu285, Arg337 | 2 |
| Trp53, Arg72, Pro128, Met133, Cys135, Gln136, Cys141, Val143, Thr150, Pro151, Lys164, Gly199, Tyr205, Arg213, Tyr236, Met246, Arg267, Phe270, Val272, Ala276, Pro278, Gly279, Asp281, Thr284, Glu286, Arg290, Lys292, Ile331, Glu349, Met384, Phe385 | 1 each |
The number of patients showing 1 of the respective mutations indicated is depicted.
These are the known hotspot mutation residues located in the DNA-binding domain of TP53.40