Patients with TP53 mutations within cytogenetic subgroups
| Cytogenetic subtype (patients mutated/studied) . | TP53 mutation (% of respective subgroup) . | P value (TP53 mutated patients vs total cohort) . |
|---|---|---|
| Low hypodiploid (n = 22/24) | 91.7 | <.0001 |
| MYC-rearrangement (n = 25/40) | 62.5 | <.0001 |
| Complex karyotype (n = 16/69) | 23.2 | <.0001 |
| BCR-ABL1 fusion gene (n = 7/162) | 4.3 | <.0001 |
| Normal karyotype (n = 13/101) | 12.9 | n.s. |
| MLL-rearrangement (n = 6/37) | 16.2 | n.s. |
| High hyperdiploid (n = 3/38) | 6.1 | n.s. |
| Other cytogenetic abnormalities (n = 6/139) | 4.3 | n.s. |
| ETV6-RUNX1 fusion gene (n = 0/15) | 0.0 | n.s. |
| Cytogenetic subtype (patients mutated/studied) . | TP53 mutation (% of respective subgroup) . | P value (TP53 mutated patients vs total cohort) . |
|---|---|---|
| Low hypodiploid (n = 22/24) | 91.7 | <.0001 |
| MYC-rearrangement (n = 25/40) | 62.5 | <.0001 |
| Complex karyotype (n = 16/69) | 23.2 | <.0001 |
| BCR-ABL1 fusion gene (n = 7/162) | 4.3 | <.0001 |
| Normal karyotype (n = 13/101) | 12.9 | n.s. |
| MLL-rearrangement (n = 6/37) | 16.2 | n.s. |
| High hyperdiploid (n = 3/38) | 6.1 | n.s. |
| Other cytogenetic abnormalities (n = 6/139) | 4.3 | n.s. |
| ETV6-RUNX1 fusion gene (n = 0/15) | 0.0 | n.s. |
n.s., not significant.