Univariate and multivariate Cox regression analysis for OS
| . | Univariate . | Multivariate . | ||
|---|---|---|---|---|
| HR . | P value . | HR . | P value . | |
| TP53 2hits | 3.7 | <.0001 | 2.4 | <.0001 |
| Age <60 vs ≥60 y | 2.9 | <.0001 | 2.8 | <.0001 |
| MYC translocated | 3.3 | <.0001 | 2.1 | .025 |
| MLL translocated | 2.3 | .005 | 2.1 | .017 |
| Low hypodiploid | 2.5 | .004 | — | n.s. |
| Complex karyotype | — | n.s. | — | — |
| BCR-ABL1 rearrangement | 0.5 | .009 | 0.6 | .03 |
| . | Univariate . | Multivariate . | ||
|---|---|---|---|---|
| HR . | P value . | HR . | P value . | |
| TP53 2hits | 3.7 | <.0001 | 2.4 | <.0001 |
| Age <60 vs ≥60 y | 2.9 | <.0001 | 2.8 | <.0001 |
| MYC translocated | 3.3 | <.0001 | 2.1 | .025 |
| MLL translocated | 2.3 | .005 | 2.1 | .017 |
| Low hypodiploid | 2.5 | .004 | — | n.s. |
| Complex karyotype | — | n.s. | — | — |
| BCR-ABL1 rearrangement | 0.5 | .009 | 0.6 | .03 |
n.s., not significant.
TP53 2hits: TP53 mutation + TP53 deletion, homozygous TP53 mutation, 2 TP53 mutations; low hypodiploid: 32-39 chromosomes; complex: >3 cytogenetic aberrations.