Prognostic factors with associated hazard ratios and P values, by both univariate and multivariate analyses
| Variable . | Risk factor . | Reference univariate analysis . | Hazard ratio (95% CI) . | P value . |
|---|---|---|---|---|
| Age | ≥60 | <60 | 1.622 (1.177, 2.234) | .003 |
| ECOG PS | 2-4 | 0-1 | 1.772 (1.304, 2.805) | .001 |
| WBC | ≥103 | <103 | 2.249 (1.694, 4.349) | <.001 |
| Albumin | <4 | ≥4 | 1.864 (1.318, 3.026) | .001 |
| LDH | >3× ULN | ≤3× ULN | 1.907 (1.131, 2.609) | .011 |
| B symptoms | Present | Absent | 1.587 (1.083, 2.414) | .019 |
| Extranodal disease | >1 site | 0-1 site | 1.518 (1.099, 2.294) | .014 |
| Ann Arbor Stage | 3-4 | 1-2 | 2.607 (1.373, 3.138) | .001 |
| Bone marrow involvement | Positive | Negative | 1.906 (1.357, 2.851) | <.001 |
| CNS involvement | Present | Absent | 4.700 (3.763, 24.77) | <.001 |
| Multivariate analysis | ||||
| WBC | ≥103 | <103 | 1.710 (1.001, 2.923) | .05 |
| LDH | >3× ULN | ≤3× ULN | 1.727 (1.000, 3.018) | .05 |
| Ann Arbor Stage | 3-4 | 1-2 | 1.585 (1.351, 3.138) | .014 |
| CNS involvement | Present | Absent | 2.000 (1.169, 3.423) | .011 |
| Variable . | Risk factor . | Reference univariate analysis . | Hazard ratio (95% CI) . | P value . |
|---|---|---|---|---|
| Age | ≥60 | <60 | 1.622 (1.177, 2.234) | .003 |
| ECOG PS | 2-4 | 0-1 | 1.772 (1.304, 2.805) | .001 |
| WBC | ≥103 | <103 | 2.249 (1.694, 4.349) | <.001 |
| Albumin | <4 | ≥4 | 1.864 (1.318, 3.026) | .001 |
| LDH | >3× ULN | ≤3× ULN | 1.907 (1.131, 2.609) | .011 |
| B symptoms | Present | Absent | 1.587 (1.083, 2.414) | .019 |
| Extranodal disease | >1 site | 0-1 site | 1.518 (1.099, 2.294) | .014 |
| Ann Arbor Stage | 3-4 | 1-2 | 2.607 (1.373, 3.138) | .001 |
| Bone marrow involvement | Positive | Negative | 1.906 (1.357, 2.851) | <.001 |
| CNS involvement | Present | Absent | 4.700 (3.763, 24.77) | <.001 |
| Multivariate analysis | ||||
| WBC | ≥103 | <103 | 1.710 (1.001, 2.923) | .05 |
| LDH | >3× ULN | ≤3× ULN | 1.727 (1.000, 3.018) | .05 |
| Ann Arbor Stage | 3-4 | 1-2 | 1.585 (1.351, 3.138) | .014 |
| CNS involvement | Present | Absent | 2.000 (1.169, 3.423) | .011 |
ECOG PS, Eastern Cooperative Oncology Group performance status; WBC, white blood cell count, in 103 cells/mL; LDH, lactate dehydrogenase, in U/L; CNS, central nervous system; ULN, upper limit of normal.