Characteristics of patients with invasive or recurrent bacterial infection
| Age (y) . | Infection history . | IgG (mg/dL) . | IgA (mg/dL) . | IgM (mg/dL) . | IgM+IgD+CD27+ (%) . | IgM−IgD−CD27+ (%) . |
|---|---|---|---|---|---|---|
| Invasive | ||||||
| 2.5 | Pneumococcal meningitis and recurrent skin infection | 944 | 41 | 81 | NA | NA |
| 3 | Pneumococcal meningitis, Haemophilus influenzae type B meningitis, and myocarditis | 703 | 63 | 102 | 4.7 | 8 |
| 3 | Pneumococcal meningitis and recurrent skin infection | 539 | 32 | 77 | 5.9 | 2.1 |
| 3 | Recurrent pneumococcal meningitis | 719 | 40 | 41 | 8.8 | 2.3 |
| 5 | Pneumococcal sepsis and recurrent pneumonia | 889 | 43 | 61 | 1.59 | 6.3 |
| 7 | Pneumococcal meningitis and sepsis | 573 | 131 | 88 | 9.2 | 8 |
| 10 | Pneumococcal meningitis | 1850 | 76 | 100 | ND | ND |
| Recurrent | ||||||
| 8 | RPI | 1060 | 66 | 123 | 10.7 | 6.5 |
| 4 | Recurrent pyogenic skin infections | 1010 | 41 | 81 | 7.3 | 5.6 |
| 6 | Recurrent pneumonia, recurrent sinusitis and otitis | 889 | 58 | 101 | 11 | 10.8 |
| 4 | Recurrent pneumonia, recurrent sinusitis and otitis | 924 | 67 | 74 | 5.9 | 2.8 |
| 2 | Recurrent pneumonia | 437 | 34 | 60 | 6 | 2.8 |
| 30 | Recurrent sinusitis | 1160 | 0 | 135 | ND | ND |
| 11 | Recurrent pneumonia and otitis | 959 | 276 | 111 | ND | ND |
| Normal reference values | ||||||
| 1-3 y | 335-896 | 27-122 | 58-153 | 5-12 | 2-10 | |
| 3-7 y | 549-1154 | 41-157 | 54-155 | 5-12 | 2-10 | |
| >7 y | 655-1278 | 70-344 | 50-209 | 5-12 | 2-10 | |
| Age (y) . | Infection history . | IgG (mg/dL) . | IgA (mg/dL) . | IgM (mg/dL) . | IgM+IgD+CD27+ (%) . | IgM−IgD−CD27+ (%) . |
|---|---|---|---|---|---|---|
| Invasive | ||||||
| 2.5 | Pneumococcal meningitis and recurrent skin infection | 944 | 41 | 81 | NA | NA |
| 3 | Pneumococcal meningitis, Haemophilus influenzae type B meningitis, and myocarditis | 703 | 63 | 102 | 4.7 | 8 |
| 3 | Pneumococcal meningitis and recurrent skin infection | 539 | 32 | 77 | 5.9 | 2.1 |
| 3 | Recurrent pneumococcal meningitis | 719 | 40 | 41 | 8.8 | 2.3 |
| 5 | Pneumococcal sepsis and recurrent pneumonia | 889 | 43 | 61 | 1.59 | 6.3 |
| 7 | Pneumococcal meningitis and sepsis | 573 | 131 | 88 | 9.2 | 8 |
| 10 | Pneumococcal meningitis | 1850 | 76 | 100 | ND | ND |
| Recurrent | ||||||
| 8 | RPI | 1060 | 66 | 123 | 10.7 | 6.5 |
| 4 | Recurrent pyogenic skin infections | 1010 | 41 | 81 | 7.3 | 5.6 |
| 6 | Recurrent pneumonia, recurrent sinusitis and otitis | 889 | 58 | 101 | 11 | 10.8 |
| 4 | Recurrent pneumonia, recurrent sinusitis and otitis | 924 | 67 | 74 | 5.9 | 2.8 |
| 2 | Recurrent pneumonia | 437 | 34 | 60 | 6 | 2.8 |
| 30 | Recurrent sinusitis | 1160 | 0 | 135 | ND | ND |
| 11 | Recurrent pneumonia and otitis | 959 | 276 | 111 | ND | ND |
| Normal reference values | ||||||
| 1-3 y | 335-896 | 27-122 | 58-153 | 5-12 | 2-10 | |
| 3-7 y | 549-1154 | 41-157 | 54-155 | 5-12 | 2-10 | |
| >7 y | 655-1278 | 70-344 | 50-209 | 5-12 | 2-10 | |
RPI, recurrent pyogenic infection.