Description of patient characteristics: clinical and laboratory
| . | Distribution of FLT3-ITD AR intervals, no. (%) . | . | |||
|---|---|---|---|---|---|
| Characteristics . | First (n = 81) . | Second (n = 80) . | Third (n = 81) . | Fourth (n = 81) . | P value . |
| Age, years | .96 | ||||
| Median | 48.9 | 48.4 | 46.9 | 47.2 | |
| Range | 18.4-60.9 | 18.3-60.7 | 19.1-61.0 | 20.5-60.8 | |
| Gender | .22 | ||||
| Male | 42 (51.9) | 32 (40) | 31 (38.3) | 40 (49.4) | |
| Female | 39 (48.2) | 48 (60) | 50 (61.7) | 41 (50.6) | |
| Type of AML | .69 | ||||
| De novo | 76 (93.8) | 76 (95) | 80 (98.8) | 78 (96.3) | |
| Secondary | 3 (3.7) | 2 (2.5) | — | 1 (1.2) | |
| Therapy-related | 2 (2.5) | 2 (2.5) | 1 (1.2) | 2 (2.5) | |
| Hemoglobin, g/dL | .44 | ||||
| Median | 9.3 | 8.6 | 9.3 | 8.9 | |
| Range | — | — | 1 | 1 | |
| WBC, ×109/L | <.0001 | ||||
| Median | 20.0 | 24.1 | 60.7 | 72.3 | |
| Range | 0.8-238.2 | 0.7-349 | 2-345 | 0.2*372 | |
| No. missing | — | — | 1 | 1 | |
| Platelet count, ×109/L | .20 | ||||
| Median | 75 | 63 | 55.5 | 58 | |
| Range | 10-545 | 14-688 | 16-248 | 8-734 | |
| No. missing | — | — | 1 | 1 | |
| LDH value, U/L | <.0001 | ||||
| Median | 424 | 522 | 734 | 788.5 | |
| Range | 176-1791 | 123-4610 | 197-4091 | 130-3261 | |
| No. missing | 4 | 3 | — | 1 | |
| Percentage of BM blasts | <.0001 | ||||
| Median | 80 | 80 | 90 | 88 | |
| Range | 20-99 | 10-100 | 2-100 | 10-100 | |
| No. missing | 4 | 6 | 5 | 1 | |
| Karyotype | .08 | ||||
| Normal | 71 (87.7) | 78 (97.5) | 73 (90.1) | 72 (88.9) | |
| Abnormal | 10 (12.3) | 2 (2.5) | 8 (9.9) | 9 (11.1) | |
| Molecular genetic abnormalities | |||||
| FLT3-TKD–mutated | 9 (11.4) | 3 (4.1) | 2 (2.5) | 2 (2.6) | .07 |
| No. missing | 2 | 6 | 2 | 3 | |
| CEBPA sm | 3 (4.0) | 5 (6.5) | 6 (7.7) | 3 (4.6) | .75 |
| No. missing | 5 | 3 | 3 | 16 | |
| CEBPA dm | 5 (6.6) | 1 (1.3) | — | — | .009 |
| No. missing | 5 | 3 | 3 | 16 | |
| NPM1-mutated | 46 (56.8) | 50 (62.5) | 52 (65) | 50 (61.7) | .76 |
| No. missing | — | — | 1 | — | |
| DNMT3A-mutated | 23 (34.9) | 18 (27.3) | 31 (47.7) | 28 (37.8) | .11 |
| No. missing | 15 | 14 | 16 | 7 | |
| IDH1-mutated | 11 (15.7) | 9 (13.0) | 6 (8.7) | 1 (1.6) | .02 |
| No. missing | 11 | 11 | 12 | 19 | |
| IDH2-mutated | 8 (11.6) | 4 (5.8) | 2 (2.9) | 2 (3.2) | .15 |
| No. missing | 12 | 11 | 12 | 19 | |
| ASXL1-mutated | 3 (4.5) | 1 (1.5) | 1 (1.5) | 1 (1.6) | .67 |
| No. missing | 14 | 12 | 12 | 20 | |
| RUNX1-mutated | 5 (7.4) | 8 (11.6) | 3 (4.4) | 6 (9.9) | .44 |
| No. missing | 13 | 11 | 12 | 20 | |
| IS JMD | 32 (69.6) | 41 (56.9) | 54 (71.0) | 39 (63.9) | .30 |
| TKD1 | 14 (30.4) | 31 (43.1) | 22 (29.0) | 22 (36.1) | |
| No. missing | 35 | 8 | 5 | 20 | |
| Length in amino acids | .05 | ||||
| Median | 14 | 18.5 | 14 | 15 | |
| Range | 5-41 | 5-65 | 5-52 | 5-40 | |
| No. missing | 35 | 8 | 5 | 20 | |
| . | Distribution of FLT3-ITD AR intervals, no. (%) . | . | |||
|---|---|---|---|---|---|
| Characteristics . | First (n = 81) . | Second (n = 80) . | Third (n = 81) . | Fourth (n = 81) . | P value . |
| Age, years | .96 | ||||
| Median | 48.9 | 48.4 | 46.9 | 47.2 | |
| Range | 18.4-60.9 | 18.3-60.7 | 19.1-61.0 | 20.5-60.8 | |
| Gender | .22 | ||||
| Male | 42 (51.9) | 32 (40) | 31 (38.3) | 40 (49.4) | |
| Female | 39 (48.2) | 48 (60) | 50 (61.7) | 41 (50.6) | |
| Type of AML | .69 | ||||
| De novo | 76 (93.8) | 76 (95) | 80 (98.8) | 78 (96.3) | |
| Secondary | 3 (3.7) | 2 (2.5) | — | 1 (1.2) | |
| Therapy-related | 2 (2.5) | 2 (2.5) | 1 (1.2) | 2 (2.5) | |
| Hemoglobin, g/dL | .44 | ||||
| Median | 9.3 | 8.6 | 9.3 | 8.9 | |
| Range | — | — | 1 | 1 | |
| WBC, ×109/L | <.0001 | ||||
| Median | 20.0 | 24.1 | 60.7 | 72.3 | |
| Range | 0.8-238.2 | 0.7-349 | 2-345 | 0.2*372 | |
| No. missing | — | — | 1 | 1 | |
| Platelet count, ×109/L | .20 | ||||
| Median | 75 | 63 | 55.5 | 58 | |
| Range | 10-545 | 14-688 | 16-248 | 8-734 | |
| No. missing | — | — | 1 | 1 | |
| LDH value, U/L | <.0001 | ||||
| Median | 424 | 522 | 734 | 788.5 | |
| Range | 176-1791 | 123-4610 | 197-4091 | 130-3261 | |
| No. missing | 4 | 3 | — | 1 | |
| Percentage of BM blasts | <.0001 | ||||
| Median | 80 | 80 | 90 | 88 | |
| Range | 20-99 | 10-100 | 2-100 | 10-100 | |
| No. missing | 4 | 6 | 5 | 1 | |
| Karyotype | .08 | ||||
| Normal | 71 (87.7) | 78 (97.5) | 73 (90.1) | 72 (88.9) | |
| Abnormal | 10 (12.3) | 2 (2.5) | 8 (9.9) | 9 (11.1) | |
| Molecular genetic abnormalities | |||||
| FLT3-TKD–mutated | 9 (11.4) | 3 (4.1) | 2 (2.5) | 2 (2.6) | .07 |
| No. missing | 2 | 6 | 2 | 3 | |
| CEBPA sm | 3 (4.0) | 5 (6.5) | 6 (7.7) | 3 (4.6) | .75 |
| No. missing | 5 | 3 | 3 | 16 | |
| CEBPA dm | 5 (6.6) | 1 (1.3) | — | — | .009 |
| No. missing | 5 | 3 | 3 | 16 | |
| NPM1-mutated | 46 (56.8) | 50 (62.5) | 52 (65) | 50 (61.7) | .76 |
| No. missing | — | — | 1 | — | |
| DNMT3A-mutated | 23 (34.9) | 18 (27.3) | 31 (47.7) | 28 (37.8) | .11 |
| No. missing | 15 | 14 | 16 | 7 | |
| IDH1-mutated | 11 (15.7) | 9 (13.0) | 6 (8.7) | 1 (1.6) | .02 |
| No. missing | 11 | 11 | 12 | 19 | |
| IDH2-mutated | 8 (11.6) | 4 (5.8) | 2 (2.9) | 2 (3.2) | .15 |
| No. missing | 12 | 11 | 12 | 19 | |
| ASXL1-mutated | 3 (4.5) | 1 (1.5) | 1 (1.5) | 1 (1.6) | .67 |
| No. missing | 14 | 12 | 12 | 20 | |
| RUNX1-mutated | 5 (7.4) | 8 (11.6) | 3 (4.4) | 6 (9.9) | .44 |
| No. missing | 13 | 11 | 12 | 20 | |
| IS JMD | 32 (69.6) | 41 (56.9) | 54 (71.0) | 39 (63.9) | .30 |
| TKD1 | 14 (30.4) | 31 (43.1) | 22 (29.0) | 22 (36.1) | |
| No. missing | 35 | 8 | 5 | 20 | |
| Length in amino acids | .05 | ||||
| Median | 14 | 18.5 | 14 | 15 | |
| Range | 5-41 | 5-65 | 5-52 | 5-40 | |
| No. missing | 35 | 8 | 5 | 20 | |