Response to induction therapy and time to event outcome
| . | Distribution of FLT3-ITD AR intervals, no. (%) . | . | |||
|---|---|---|---|---|---|
| Outcome . | First (n = 81) . | Second (n = 80) . | Third (n = 81) . | Fourth (n = 81) . | P value . |
| CR | 66 (81.5) | 63 (79.8) | 56 (69.1) | 46 (57.5) | .003 |
| RD | 11 | 12 (15.2) | 17 (21.0) | 30 (37.5) | .001 |
| ED | 4 (4.9) | 4 (5.0) | 8 (9.9) | 4 (5.0) | .53 |
| OS (median), years | 2.19 | 2.15 | 1.20 | 0.90 | .0006 |
| RFS (median), years | 1.08 | 1.42 | 0.76 | 0.67 | .26 |
| EFS (median), years | 0.75 | 0.81 | 0.49 | 0.25 | .001 |
| IS in the JMD | |||||
| CR | 29 (91) | 35 (85) | 37 (69) | 22 (56) | .002 |
| No. missing | 28 | 8 | 5 | 12 | |
| RD | 2 (6) | 4 (10) | 13 (24) | 14 (36) | .004 |
| No. missing | 6 | 0 | 0 | 7 | |
| ED | 1 (3) | 2 (5) | 4 (7) | 3 (8) | .87 |
| No. missing | 1 | 0 | 0 | 0 | |
| IS in the TKD1 | |||||
| CR | 9 (64.3) | 20 (66.7) | 14 (64) | 12 (54.5) | .84 |
| No. missing | 28 | 8 | 5 | 12 | |
| RD | 3 (21.4) | 8 (26.7) | 4 (18) | 9 (41) | .39 |
| No. missing | 6 | 0 | 0 | 7 | |
| ED | 2 (14.3) | 2 (6.7) | 4 (18) | 1 (4.5) | .41 |
| No. missing | 1 | 0 | 0 | 0 | |
| . | Distribution of FLT3-ITD AR intervals, no. (%) . | . | |||
|---|---|---|---|---|---|
| Outcome . | First (n = 81) . | Second (n = 80) . | Third (n = 81) . | Fourth (n = 81) . | P value . |
| CR | 66 (81.5) | 63 (79.8) | 56 (69.1) | 46 (57.5) | .003 |
| RD | 11 | 12 (15.2) | 17 (21.0) | 30 (37.5) | .001 |
| ED | 4 (4.9) | 4 (5.0) | 8 (9.9) | 4 (5.0) | .53 |
| OS (median), years | 2.19 | 2.15 | 1.20 | 0.90 | .0006 |
| RFS (median), years | 1.08 | 1.42 | 0.76 | 0.67 | .26 |
| EFS (median), years | 0.75 | 0.81 | 0.49 | 0.25 | .001 |
| IS in the JMD | |||||
| CR | 29 (91) | 35 (85) | 37 (69) | 22 (56) | .002 |
| No. missing | 28 | 8 | 5 | 12 | |
| RD | 2 (6) | 4 (10) | 13 (24) | 14 (36) | .004 |
| No. missing | 6 | 0 | 0 | 7 | |
| ED | 1 (3) | 2 (5) | 4 (7) | 3 (8) | .87 |
| No. missing | 1 | 0 | 0 | 0 | |
| IS in the TKD1 | |||||
| CR | 9 (64.3) | 20 (66.7) | 14 (64) | 12 (54.5) | .84 |
| No. missing | 28 | 8 | 5 | 12 | |
| RD | 3 (21.4) | 8 (26.7) | 4 (18) | 9 (41) | .39 |
| No. missing | 6 | 0 | 0 | 7 | |
| ED | 2 (14.3) | 2 (6.7) | 4 (18) | 1 (4.5) | .41 |
| No. missing | 1 | 0 | 0 | 0 | |