Potential reasons for early transplant vs reasons to wait for transplant in children with less severe SCD
| Transplant early to: . | Wait to consider transplant because: . |
|---|---|
| Prevent early organ damage secondary to SCD | Advances in HSCT technology may further improve HSCT outcomes in the future |
| Avoid SCD complications in childhood | Other curative therapy (gene therapy) may be developed in future with less risks than HSCT |
| Achieve better HSCT outcomes secondary to less pre-HSCT organ damage and alloimmunization | Further improvement in SCD supportive care (new medications other than hydroxyurea) may make curative therapy less important |
| Transplant early to: . | Wait to consider transplant because: . |
|---|---|
| Prevent early organ damage secondary to SCD | Advances in HSCT technology may further improve HSCT outcomes in the future |
| Avoid SCD complications in childhood | Other curative therapy (gene therapy) may be developed in future with less risks than HSCT |
| Achieve better HSCT outcomes secondary to less pre-HSCT organ damage and alloimmunization | Further improvement in SCD supportive care (new medications other than hydroxyurea) may make curative therapy less important |