Multivariate analysis
| Variable‡ . | RFS* . | OS† . | ||
|---|---|---|---|---|
| HR (95% CI) . | P . | HR (95% CI) . | P . | |
| Age (10 y increase) | 1.33 (1.21-1.46) | <.001 | 1.38 (1.27-1.5) | <.001 |
| BM blasts on day 16 (10% increase) | 1.04 (0.97-1.09) | .08 | 1.02 (1.02-1.09) | .002 |
| WBC (10 G/l increase) | 1.02 (0.99-1.05) | .15 | 1.02 (1-1.05) | .04 |
| de novo vs secondary AML | 1.02 (0.75-1.4) | .89 | 1.26 (1-1.59) | .05 |
| AML+13 | 1.47 (0.82-2.62) | .2 | 1.65 (1.03-2.63) | .04 |
| Variable‡ . | RFS* . | OS† . | ||
|---|---|---|---|---|
| HR (95% CI) . | P . | HR (95% CI) . | P . | |
| Age (10 y increase) | 1.33 (1.21-1.46) | <.001 | 1.38 (1.27-1.5) | <.001 |
| BM blasts on day 16 (10% increase) | 1.04 (0.97-1.09) | .08 | 1.02 (1.02-1.09) | .002 |
| WBC (10 G/l increase) | 1.02 (0.99-1.05) | .15 | 1.02 (1-1.05) | .04 |
| de novo vs secondary AML | 1.02 (0.75-1.4) | .89 | 1.26 (1-1.59) | .05 |
| AML+13 | 1.47 (0.82-2.62) | .2 | 1.65 (1.03-2.63) | .04 |
Significant P values are indicated in bold.
n = 378, number of events = 275 (114 patients excluded due to missing covariables).
n = 549, number of events = 410 (335 patients excluded due to missing covariables).
Only variables with P ≤ .05 in either model are shown. The following variables were included in both models: sex, age (continuous variable), BM blasts at initial diagnosis and day 16, ECOG performance status, WBC count, platelet count, hemoglobin, serum LDH level, de novo vs secondary AML, and AML+13 status.