Table 1

General considerations in relapsed myeloma

VariableConsiderations
Components of the initial therapy Novel agents? 
ASCT? 
Degree and duration of response to primary therapy PR, VGPR, CR? 
≥6 mo, ≥1 y? 
Previous toxicities Myelosuppression 
Peripheral neuropathy 
Type of relapse Aggressive 
Indolent 
Age and performance status Elderly 
Frail 
VariableConsiderations
Components of the initial therapy Novel agents? 
ASCT? 
Degree and duration of response to primary therapy PR, VGPR, CR? 
≥6 mo, ≥1 y? 
Previous toxicities Myelosuppression 
Peripheral neuropathy 
Type of relapse Aggressive 
Indolent 
Age and performance status Elderly 
Frail 

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