Association of TNFR1, IL-8, REG3α, IL2Rα, Elafin, and HGF with grade II-IV aGVHD, grade III-IV aGVHD, and TRM in 113 DCBT recipients
| Day 28 biomarker . | Day 180 Grade II-IV aGVHD, % (95% CI) . | P . | Day 180 Grade III-IV aGVHD, % (95% CI) . | P . | Day 180 TRM, % (95% CI) . | P . |
|---|---|---|---|---|---|---|
| TNFR1, pg/mL | ||||||
| ≤4792 | 60 (46-72) | .749 | 23 (12-35) | .645 | 5 (1-13) | .005 |
| >4792 | 57 (42-69) | 19 (10-31) | 23 (13-35) | |||
| IL-8, pg/mL | ||||||
| ≤51 | 59 (45-71) | .822 | 15 (7-26) | .147 | 5 (1-13) | .005 |
| >51 | 58 (43-70) | 27 (16-40) | 23 (13-35) | |||
| REG3α,ng/mL | ||||||
| ≤42 | 59 (44-71) | .922 | 25 (14-37) | .361 | 5 (1-13) | .032 |
| >42 | 59 (44-71) | 17 (8-28) | 24 (13-36) | |||
| IL2Rα, pg/mL | ||||||
| ≤2426 | 57 (42-69) | .830 | 21 (11-33) | .978 | 12 (5-22) | .081 |
| >2426 | 60 (46-72) | 21 (11-33) | 16 (8-27) | |||
| Elafin, pg/mL | ||||||
| ≤5155 | 56 (41-68) | .283 | 21 (11-33) | .996 | 11 (4-20) | .296 |
| >5155 | 61 (47-73) | 20 (11-32) | 18 (9-29) | |||
| HGF, pg/mL | ||||||
| ≤940 | 64 (49-76) | .368 | 25 (14-37) | .388 | 12 (5-22) | .919 |
| >940 | 53 (39-65) | 17 (8-28) | 16 (8-27) |
| Day 28 biomarker . | Day 180 Grade II-IV aGVHD, % (95% CI) . | P . | Day 180 Grade III-IV aGVHD, % (95% CI) . | P . | Day 180 TRM, % (95% CI) . | P . |
|---|---|---|---|---|---|---|
| TNFR1, pg/mL | ||||||
| ≤4792 | 60 (46-72) | .749 | 23 (12-35) | .645 | 5 (1-13) | .005 |
| >4792 | 57 (42-69) | 19 (10-31) | 23 (13-35) | |||
| IL-8, pg/mL | ||||||
| ≤51 | 59 (45-71) | .822 | 15 (7-26) | .147 | 5 (1-13) | .005 |
| >51 | 58 (43-70) | 27 (16-40) | 23 (13-35) | |||
| REG3α,ng/mL | ||||||
| ≤42 | 59 (44-71) | .922 | 25 (14-37) | .361 | 5 (1-13) | .032 |
| >42 | 59 (44-71) | 17 (8-28) | 24 (13-36) | |||
| IL2Rα, pg/mL | ||||||
| ≤2426 | 57 (42-69) | .830 | 21 (11-33) | .978 | 12 (5-22) | .081 |
| >2426 | 60 (46-72) | 21 (11-33) | 16 (8-27) | |||
| Elafin, pg/mL | ||||||
| ≤5155 | 56 (41-68) | .283 | 21 (11-33) | .996 | 11 (4-20) | .296 |
| >5155 | 61 (47-73) | 20 (11-32) | 18 (9-29) | |||
| HGF, pg/mL | ||||||
| ≤940 | 64 (49-76) | .368 | 25 (14-37) | .388 | 12 (5-22) | .919 |
| >940 | 53 (39-65) | 17 (8-28) | 16 (8-27) |