Phenotype of the JAK2 V617F KI mouse... | American Society of Hematology

Phenotype of the JAK2^V617F KI mouse models used in Lamrani et al¹

Phenotype	Inducible JAK2^V617F (SCLCreERt)		Constitutive JAK2^V617F (vavCre)	Suggested cause
Phenotype	Early (13 days)	Late (60 days)	Constitutive JAK2^V617F (vavCre)	Suggested cause
Reduced in vitro thrombosis	√	—	√	vWF proteolysis
Reduced large vWF multimers	√	—	√	vWF proteolysis
Platelet hypoactivity	√	—	√	Unclear
Prolonged bleeding	√	—	√	vWF proteolysis
Reduced platelet GPVI expression	—	√	√	Myelofibrosis
Vasodilation	—	√	√	Adaptation to increased blood viscosity
Clot lysis	—	√	√	Activation of proteases
Rapid in vivo formation of unstable thrombi	—	√	√	Contribution JAK2^V617F Erythrocytes/ leukocytes, thrombin generation

Phenotype	Inducible JAK2^V617F (SCLCreERt)		Constitutive JAK2^V617F (vavCre)	Suggested cause
Phenotype	Early (13 days)	Late (60 days)	Constitutive JAK2^V617F (vavCre)	Suggested cause
Reduced in vitro thrombosis	√	—	√	vWF proteolysis
Reduced large vWF multimers	√	—	√	vWF proteolysis
Platelet hypoactivity	√	—	√	Unclear
Prolonged bleeding	√	—	√	vWF proteolysis
Reduced platelet GPVI expression	—	√	√	Myelofibrosis
Vasodilation	—	√	√	Adaptation to increased blood viscosity
Clot lysis	—	√	√	Activation of proteases
Rapid in vivo formation of unstable thrombi	—	√	√	Contribution JAK2^V617F Erythrocytes/ leukocytes, thrombin generation

The hematopoietic-specific JAK2^V617F mouse models of PV/MF were generated by transplantation of bone marrow from inducible (SCLCreERt) and constitutive (VavCre) JAK2^V617F knock-in mice. For the inducible mouse model, both the early (13 days after induction of JAK2^V617F expression) and late (60 days after induction of JAK2^V617F expression) phenotypes are indicated. The underlying cause of the observed phenotype, as suggested by Lamrani et al, is also included. √, phenotype observed.

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