Comparison of meta-analyses
| Reference . | No. of studies . | No. of patients . | Type of PE . | Statistical method . | Conclusion . | Comments . |
|---|---|---|---|---|---|---|
| Meta-analysis (studies included) . | ||||||
| 8 (15-18, 20-22) | 7 | 594 | Stable | Mantel-Haenszel fixed-effect models | Efficacy: thrombolysis did not reduce overall mortality or recurrent PE in stable PE Safety: thrombolysis did not increase risk of major bleeding in stable PE | Did not include reference 24 or 25 |
| 7 (10-12, 14-25, 42) | 16 | 2115 | All | Peto fixed-effect models | Efficacy: thrombolysis reduced overall mortality in all PE and stable PE, and reduced PE recurrence in all PE Safety: thrombolysis increased risk of major bleeding in all PE and stable PE | The only meta-analysis that used the Peto statistical method; did not include reference 13; the only meta-analysis that combined reference 42 into the analysis |
| 6 (10, 12-25) | 15 | 2057 | All | Mantel-Haenszel fixed-effect models | Efficacy: thrombolysis reduced overall mortality, PE-related mortality, and PE recurrence in all PE but not after high-risk PE was excluded Safety: thrombolysis increased risk of major bleeding in all PE | Did not include reference 11 or 42 |
| 5 (18, 20-22, 24,25) | 6 | 1510 | Stable | Mantel-Haenszel random-effect models | Efficacy: thrombolysis did not reduce risk of mortality or recurrent PE in stable PE Safety: thrombolysis did not increase risk of major bleeding in stable PE | The only meta-analysis that used the Mantel-Haenszel random-effect models; did not include reference 23 |
| Current study (10-25) | 16 | 2087 | All | Mantel-Haenszel fixed-effect models | Efficacy: thrombolysis reduced overall mortality in all PE but not stable PE with RVD Safety: thrombolysis increased risk of major bleeding in all PE and stable PE | Reference 42 was included in the review but analyzed separately |
| Reference . | No. of studies . | No. of patients . | Type of PE . | Statistical method . | Conclusion . | Comments . |
|---|---|---|---|---|---|---|
| Meta-analysis (studies included) . | ||||||
| 8 (15-18, 20-22) | 7 | 594 | Stable | Mantel-Haenszel fixed-effect models | Efficacy: thrombolysis did not reduce overall mortality or recurrent PE in stable PE Safety: thrombolysis did not increase risk of major bleeding in stable PE | Did not include reference 24 or 25 |
| 7 (10-12, 14-25, 42) | 16 | 2115 | All | Peto fixed-effect models | Efficacy: thrombolysis reduced overall mortality in all PE and stable PE, and reduced PE recurrence in all PE Safety: thrombolysis increased risk of major bleeding in all PE and stable PE | The only meta-analysis that used the Peto statistical method; did not include reference 13; the only meta-analysis that combined reference 42 into the analysis |
| 6 (10, 12-25) | 15 | 2057 | All | Mantel-Haenszel fixed-effect models | Efficacy: thrombolysis reduced overall mortality, PE-related mortality, and PE recurrence in all PE but not after high-risk PE was excluded Safety: thrombolysis increased risk of major bleeding in all PE | Did not include reference 11 or 42 |
| 5 (18, 20-22, 24,25) | 6 | 1510 | Stable | Mantel-Haenszel random-effect models | Efficacy: thrombolysis did not reduce risk of mortality or recurrent PE in stable PE Safety: thrombolysis did not increase risk of major bleeding in stable PE | The only meta-analysis that used the Mantel-Haenszel random-effect models; did not include reference 23 |
| Current study (10-25) | 16 | 2087 | All | Mantel-Haenszel fixed-effect models | Efficacy: thrombolysis reduced overall mortality in all PE but not stable PE with RVD Safety: thrombolysis increased risk of major bleeding in all PE and stable PE | Reference 42 was included in the review but analyzed separately |