Table 1 Preclinical injury models... | American Society of Hematology

Table 1

Preclinical injury models showing beneficial effects of wt-APC

Model	Trigger	End point	APC’s effects	Reference
Thrombus formation	Procoagulant trigger	Thrombus size	Reduction	52, 53
Thrombus resolution	Existing thrombosis	Thrombus size	Accelerated reduction	54
Sepsis	Endotoxin; bacteremia	Death; inflammation	Reduction	1, 55
Cerebral I/R	Ischemia	Infarction; swelling; neurologic score	Reduction	6, 56-58
Cardiac I/R	Ischemia	Infarction; death	Reduction	59-63
Kidney I/R	Ischemia	Death	Reduction	4
Retina I/R	Ischemia	Microvascular circulation	Improved	64
Liver I/R	Ischemia	Organ function	Improvement	65
Lung injury	Asthma; bacteria	Pulmonary function; inflammation; death	Reduction; prevent death	1
Intestinal injury	DSS-induced colitis	Healing	Reduction	1, 66, 67
Type I diabetes	Diabetes propensity	Incidence; pancreatic islets	Reduction; increase	16, 68, 69
Nephropathy	Diabetes	Kidney damage	Reduction	16, 70, 71
Islet transplant	Diabetes	Cell count; glucose level	Improvement	72
Liver transplant	Surgery	Organ function	Improvement	73
Wound healing	Skin injury	Healing	Promotion	14, 74
Angiogenesis	varied	Vessel growth	Promotion	17, 75
Total body radiation	Lethal radiation	Death	Reduction	76
Traumatic brain injury	Controlled cortical impact	Infarction; angiogenesis; neurogenesis	Reduce damage; promote healing	77
Amyotrophic lateral sclerosis	SOD1 mutation	Symptom onset; death	Reduction	24
EAE	Immunogen	Clinical score	Improvement	78
Neurogenesis	Ischemia	Neuron growth	Increase	17
Ebola virus disease	Infection	Death; time to death	Reduction; delayed	79
Postsurgical adhesion band	Surgery	Adhesion bands	Reduced	80

Model	Trigger	End point	APC’s effects	Reference
Thrombus formation	Procoagulant trigger	Thrombus size	Reduction	52, 53
Thrombus resolution	Existing thrombosis	Thrombus size	Accelerated reduction	54
Sepsis	Endotoxin; bacteremia	Death; inflammation	Reduction	1, 55
Cerebral I/R	Ischemia	Infarction; swelling; neurologic score	Reduction	6, 56-58
Cardiac I/R	Ischemia	Infarction; death	Reduction	59-63
Kidney I/R	Ischemia	Death	Reduction	4
Retina I/R	Ischemia	Microvascular circulation	Improved	64
Liver I/R	Ischemia	Organ function	Improvement	65
Lung injury	Asthma; bacteria	Pulmonary function; inflammation; death	Reduction; prevent death	1
Intestinal injury	DSS-induced colitis	Healing	Reduction	1, 66, 67
Type I diabetes	Diabetes propensity	Incidence; pancreatic islets	Reduction; increase	16, 68, 69
Nephropathy	Diabetes	Kidney damage	Reduction	16, 70, 71
Islet transplant	Diabetes	Cell count; glucose level	Improvement	72
Liver transplant	Surgery	Organ function	Improvement	73
Wound healing	Skin injury	Healing	Promotion	14, 74
Angiogenesis	varied	Vessel growth	Promotion	17, 75
Total body radiation	Lethal radiation	Death	Reduction	76
Traumatic brain injury	Controlled cortical impact	Infarction; angiogenesis; neurogenesis	Reduce damage; promote healing	77
Amyotrophic lateral sclerosis	SOD1 mutation	Symptom onset; death	Reduction	24
EAE	Immunogen	Clinical score	Improvement	78
Neurogenesis	Ischemia	Neuron growth	Increase	17
Ebola virus disease	Infection	Death; time to death	Reduction; delayed	79
Postsurgical adhesion band	Surgery	Adhesion bands	Reduced	80

DSS, dextran sodium sulfate; EAE, experimental autoimmune encephalomyelitis; I/R, ischemia/reperfusion.