Absence of association between the rate of infections and the senescent state of T cells in patients with ICL
| Characteristics . | Asymptomatic (n = 8) . | Opportunistic infections (n = 12) . | P value . | CMV-negative (n = 12) . | CMV-positive (n = 8) . | P value . |
|---|---|---|---|---|---|---|
| CD4+ T-cell count, cells/mm3 | 162 (38-278) | 40.5 (22-219) | .05 | 100 (25-222) | 187 (22-278) | .5 |
| CD4+ T cells, % | 35.5 (3-62) | 19 (5-29) | .04 | 27 (3-62) | 23 (5-40) | .36 |
| CD27−CD28− in CD4+ T cells, % | 23.5 (3.3-30.7) | 27.5 (18.9-59.1) | .06 | 25.8 (3.3-56.4) | 23.2 (10.7-59.1) | .89 |
| KLRG1+CD57+ in CD4+ T cells, % | 7.2 (4.2-13.2) | 13 (4.5-46) | .09 | 11.3 (4.2-33.1) | 13.75 (5.5-46) | .32 |
| CD8+ T-cell count, cells/mm3 | 104 (46-691) | 102.5 (15-392) | .67 | 55 (15-691) | 132 (25-325) | .97 |
| CD8+ T cells, % | 18 (13-57) | 17.5 (9-77) | .65 | 15 (10-57) | 20 (9-77) | .3 |
| CD27−CD28− in CD8+ T cells, % | 26.3 (6.37-49.6) | 32.3 (19.8-56.4) | .20 | 32.1 (19.8-55.2) | 32.30 (6.37-56.4) | .57 |
| KLRG1+CD57+ in CD8+ T cells, % | 28 (4.4-35.6) | 22.9 (11.5-48.3) | .80 | 23.2 (4.4-48.3) | 32.25 (11.5-43.1) | .58 |
| Characteristics . | Asymptomatic (n = 8) . | Opportunistic infections (n = 12) . | P value . | CMV-negative (n = 12) . | CMV-positive (n = 8) . | P value . |
|---|---|---|---|---|---|---|
| CD4+ T-cell count, cells/mm3 | 162 (38-278) | 40.5 (22-219) | .05 | 100 (25-222) | 187 (22-278) | .5 |
| CD4+ T cells, % | 35.5 (3-62) | 19 (5-29) | .04 | 27 (3-62) | 23 (5-40) | .36 |
| CD27−CD28− in CD4+ T cells, % | 23.5 (3.3-30.7) | 27.5 (18.9-59.1) | .06 | 25.8 (3.3-56.4) | 23.2 (10.7-59.1) | .89 |
| KLRG1+CD57+ in CD4+ T cells, % | 7.2 (4.2-13.2) | 13 (4.5-46) | .09 | 11.3 (4.2-33.1) | 13.75 (5.5-46) | .32 |
| CD8+ T-cell count, cells/mm3 | 104 (46-691) | 102.5 (15-392) | .67 | 55 (15-691) | 132 (25-325) | .97 |
| CD8+ T cells, % | 18 (13-57) | 17.5 (9-77) | .65 | 15 (10-57) | 20 (9-77) | .3 |
| CD27−CD28− in CD8+ T cells, % | 26.3 (6.37-49.6) | 32.3 (19.8-56.4) | .20 | 32.1 (19.8-55.2) | 32.30 (6.37-56.4) | .57 |
| KLRG1+CD57+ in CD8+ T cells, % | 28 (4.4-35.6) | 22.9 (11.5-48.3) | .80 | 23.2 (4.4-48.3) | 32.25 (11.5-43.1) | .58 |
Data are medians (ranges). Patients were distributed according to the opportunistic infection or serological (negative, IgM− IgG−; or positive: IgM− IgG+) CMV status. P values were determined using the Mann-Whitney U test.