Table 1 Notch1 mutations in T-ALL in... | American Society of Hematology

Table 1

Notch1 mutations in T-ALL in Sur-TCR-Tg mice

Mouse	Tissue	HD domain	PEST domain	5′ NOTCH1 deletion
E8-1	T-ALL thymus	WT	66260	Neg
E8-1	T-ALL thymus	WT	C > G	Neg
E8-2	T-ALL thymus	WT	66280	Neg
E8-2	T-ALL thymus	WT	G > GTTTTCCCCCT	Neg
F8-1	T-ALL thymus	WT	66280	Pos
F8-1	T-ALL thymus	WT	G > CCG	Pos
F8-2	T-ALL thymus	WT	66280	Pos
F8-2	T-ALL thymus	WT	G > CC	Pos
L8-1	T-ALL thymus	59724	66280	Neg
		T>C	G > CC
		(Leu > Pro)
F8-3	T-ALL cell line 1	59730	66280	Neg
		T>G	G > CCG
		(Ile > Ser)
L8-2	T-ALL cell line 2	WT	66279	Pos
L8-2	T-ALL cell line 2	WT	C > AC	Pos
L8-3	T-ALL cell line 3	WT	WT	Pos
L8-4	T-ALL cell line 3	WT	66278	Neg
L8-4	T-ALL cell line 3	WT	A > ACCCCT	Neg

Mouse	Tissue	HD domain	PEST domain	5′ NOTCH1 deletion
E8-1	T-ALL thymus	WT	66260	Neg
E8-1	T-ALL thymus	WT	C > G	Neg
E8-2	T-ALL thymus	WT	66280	Neg
E8-2	T-ALL thymus	WT	G > GTTTTCCCCCT	Neg
F8-1	T-ALL thymus	WT	66280	Pos
F8-1	T-ALL thymus	WT	G > CCG	Pos
F8-2	T-ALL thymus	WT	66280	Pos
F8-2	T-ALL thymus	WT	G > CC	Pos
L8-1	T-ALL thymus	59724	66280	Neg
		T>C	G > CC
		(Leu > Pro)
F8-3	T-ALL cell line 1	59730	66280	Neg
		T>G	G > CCG
		(Ile > Ser)
L8-2	T-ALL cell line 2	WT	66279	Pos
L8-2	T-ALL cell line 2	WT	C > AC	Pos
L8-3	T-ALL cell line 3	WT	WT	Pos
L8-4	T-ALL cell line 3	WT	66278	Neg
L8-4	T-ALL cell line 3	WT	A > ACCCCT	Neg

Neg, negative; Pos, positive.