Frequency of CD8+ T-cell IFN-γ immune responses against TAAs and CMV in 44 HLA-A*02:01+ women in their first pregnancy (longitudinal study group II)
| . | First to second trimester . | 1 to 4 d after delivery . | 2 to 3 mo after delivery . | After completion of nursing . | ||||
|---|---|---|---|---|---|---|---|---|
| n . | % . | n . | % . | n . | % . | n . | % . | |
| HER2/neu | ||||||||
| 0.1 µmol/L | 0/39 | 0 | 1/31 | 3 | 0/34 | 0 | 1/13 | 8 |
| 10 µmol/L | 0/36 | 0 | 0/24 | 0 | 0/26 | 0 | 0/13 | 0 |
| 0.1 and/or 10 µmol/L | 0/43 | 0 | 1/31 | 3 | 0/34 | 0 | 1/14 | 7 |
| MUC1 | ||||||||
| 0.1 µmol/L | 4/36 | 11 | 2/31 | 6 | 1/34 | 3 | 0/11 | 0 |
| 10 µmol/L | 2/32 | 5 | 0/20 | 0 | 0/24 | 0 | 0/11 | 0 |
| 0.1 and/or 10 µmol/L | 6/43 | 14 | 2/31 | 6 | 1/34 | 3 | 0/12 | 0 |
| PRAME | ||||||||
| 0.1 µmol/L | 2/37 | 5 | 1/31 | 3 | 2/33 | 6 | 0/12 | 0 |
| 10 µmol/L | 1/33 | 3 | 2/20 | 10 | 1/25 | 3 | 0/13 | 0 |
| 0.1 and/or 10 µmol/L | 3/43 | 7 | 2/31 | 6 | 2/33 | 6 | 0/13 | 0 |
| WT1 | ||||||||
| 0.1 µmol/L | 11/41 | 27 | 3/31 | 10 | 1/34 | 3 | 0/14 | 0 |
| 10 µmol/L | 7/39 | 17 | 1/29 | 3 | 0/32 | 0 | 0/14 | 0 |
| 0.1 and/or 10 µmol/L | 13/43 | 30 | 3/31 | 10 | 1/34 | 3 | 0/14 | 0 |
| CMV | ||||||||
| 10 µmol/L | 12/23 | 52 | 6/21 | 29 | 15/30 | 50 | 8/11 | 73 |
| . | First to second trimester . | 1 to 4 d after delivery . | 2 to 3 mo after delivery . | After completion of nursing . | ||||
|---|---|---|---|---|---|---|---|---|
| n . | % . | n . | % . | n . | % . | n . | % . | |
| HER2/neu | ||||||||
| 0.1 µmol/L | 0/39 | 0 | 1/31 | 3 | 0/34 | 0 | 1/13 | 8 |
| 10 µmol/L | 0/36 | 0 | 0/24 | 0 | 0/26 | 0 | 0/13 | 0 |
| 0.1 and/or 10 µmol/L | 0/43 | 0 | 1/31 | 3 | 0/34 | 0 | 1/14 | 7 |
| MUC1 | ||||||||
| 0.1 µmol/L | 4/36 | 11 | 2/31 | 6 | 1/34 | 3 | 0/11 | 0 |
| 10 µmol/L | 2/32 | 5 | 0/20 | 0 | 0/24 | 0 | 0/11 | 0 |
| 0.1 and/or 10 µmol/L | 6/43 | 14 | 2/31 | 6 | 1/34 | 3 | 0/12 | 0 |
| PRAME | ||||||||
| 0.1 µmol/L | 2/37 | 5 | 1/31 | 3 | 2/33 | 6 | 0/12 | 0 |
| 10 µmol/L | 1/33 | 3 | 2/20 | 10 | 1/25 | 3 | 0/13 | 0 |
| 0.1 and/or 10 µmol/L | 3/43 | 7 | 2/31 | 6 | 2/33 | 6 | 0/13 | 0 |
| WT1 | ||||||||
| 0.1 µmol/L | 11/41 | 27 | 3/31 | 10 | 1/34 | 3 | 0/14 | 0 |
| 10 µmol/L | 7/39 | 17 | 1/29 | 3 | 0/32 | 0 | 0/14 | 0 |
| 0.1 and/or 10 µmol/L | 13/43 | 30 | 3/31 | 10 | 1/34 | 3 | 0/14 | 0 |
| CMV | ||||||||
| 10 µmol/L | 12/23 | 52 | 6/21 | 29 | 15/30 | 50 | 8/11 | 73 |