Correlation analysis between relative CD8+ T-cell IFN-γ immune responses against TAAs and CMV in HLA-A*02:01+ volunteer blood donors and women in their first pregnancy
| . | HER2/neu . | MUC1 . | PRAME . | WT1 . | ||||
|---|---|---|---|---|---|---|---|---|
| n . | r . | n . | r . | n . | r . | n . | r . | |
| Cross-sectional study group I | ||||||||
| All donors | 107 | 0.203* | 107 | 0.225* | 108 | 0.168 | 109 | 0.149 |
| Nulligravidous women | 36 | 0.023 | 36 | 0.252 | 36 | 0.216 | 37 | 0.034 |
| Primi-/multiparous women | 35 | 0.180 | 35 | 0.045 | 35 | 0.016 | 35 | 0.078 |
| Men | 36 | 0.347* | 36 | 0.292 | 37 | 0.205 | 37 | 0.305 |
| Longitudinal study group II | ||||||||
| First to second trimester | 18 | −0.015 | 16 | −0.124 | 17 | 0.033 | 19 | −0.056 |
| 1 to 4 d after delivery | 19 | 0.059 | 16 | 0.225 | 16 | 0.034 | 21 | 0.056 |
| 2 to 3 mo after delivery | 17 | 0.296 | 16 | 0.353 | 17 | 0.048 | 22 | 0.211 |
| After completion of nursing | 11 | −0.309 | 10 | −0.273 | 11 | −0.009 | 11 | 0.355 |
| . | HER2/neu . | MUC1 . | PRAME . | WT1 . | ||||
|---|---|---|---|---|---|---|---|---|
| n . | r . | n . | r . | n . | r . | n . | r . | |
| Cross-sectional study group I | ||||||||
| All donors | 107 | 0.203* | 107 | 0.225* | 108 | 0.168 | 109 | 0.149 |
| Nulligravidous women | 36 | 0.023 | 36 | 0.252 | 36 | 0.216 | 37 | 0.034 |
| Primi-/multiparous women | 35 | 0.180 | 35 | 0.045 | 35 | 0.016 | 35 | 0.078 |
| Men | 36 | 0.347* | 36 | 0.292 | 37 | 0.205 | 37 | 0.305 |
| Longitudinal study group II | ||||||||
| First to second trimester | 18 | −0.015 | 16 | −0.124 | 17 | 0.033 | 19 | −0.056 |
| 1 to 4 d after delivery | 19 | 0.059 | 16 | 0.225 | 16 | 0.034 | 21 | 0.056 |
| 2 to 3 mo after delivery | 17 | 0.296 | 16 | 0.353 | 17 | 0.048 | 22 | 0.211 |
| After completion of nursing | 11 | −0.309 | 10 | −0.273 | 11 | −0.009 | 11 | 0.355 |
Peptide concentration for stimulation was 10 µmol/L for TAAs and CMV.
r, Spearman’s rank correlation coefficient of relative immune responses; n, number of individuals for whom the correlation between CMV and respective TAA was performed (this number varied, as results for both antigens needed to be available for each individual).
P < .05.