Table 1

Clinical features of C κ amyloidosis

SubjectClinical featuresAge at death (y)Tissue-positive amyloidBone marrowImmunoglobulin light-chainκ131Cys
I-2 Renal failure 58     
II-1 Renal failure, age 52 53     
II-3 Renal failure, age 60 66 Kidney, larynx, lung, bone marrow Hypocellular   
Dialysis, age 64 
II-7 Renal failure 73     
Dialysis 
II-8 Renal failure 54 Kidney    
Dialysis 
II-10 Renal failure  Postmortem kidney, heart, pancreas, parathyroid Hypocellular   
Dialysis 62 + 
II-12 Renal failure, age 60+      
Dialysis 
III-2 Renal failure, age 66 74 Kidney    
Dialysis, age 70 
III-8 Alive, 73 y     – 
III-9 Proteinuria, age 64 (stage 3 renal disease)    Increased κ and λ + 
III-10 Asymptomatic, age 37     + 
III-12 Proteinuria, age 66  Kidney  Normal + 
III-15 Cholecystitis, age 53  Stomach, gall bladder Normal Normal + 
IV-1      – 
IV-2      – 
IV-3       
IV-4 Asymptomatic, age 40    Normal + 
IV-5 Asymptomatic, age 39    Normal + 
IV-6      – 
SubjectClinical featuresAge at death (y)Tissue-positive amyloidBone marrowImmunoglobulin light-chainκ131Cys
I-2 Renal failure 58     
II-1 Renal failure, age 52 53     
II-3 Renal failure, age 60 66 Kidney, larynx, lung, bone marrow Hypocellular   
Dialysis, age 64 
II-7 Renal failure 73     
Dialysis 
II-8 Renal failure 54 Kidney    
Dialysis 
II-10 Renal failure  Postmortem kidney, heart, pancreas, parathyroid Hypocellular   
Dialysis 62 + 
II-12 Renal failure, age 60+      
Dialysis 
III-2 Renal failure, age 66 74 Kidney    
Dialysis, age 70 
III-8 Alive, 73 y     – 
III-9 Proteinuria, age 64 (stage 3 renal disease)    Increased κ and λ + 
III-10 Asymptomatic, age 37     + 
III-12 Proteinuria, age 66  Kidney  Normal + 
III-15 Cholecystitis, age 53  Stomach, gall bladder Normal Normal + 
IV-1      – 
IV-2      – 
IV-3       
IV-4 Asymptomatic, age 40    Normal + 
IV-5 Asymptomatic, age 39    Normal + 
IV-6      – 
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