Table 1

Levels of evidence for drugs reported to cause TMA

Levels of evidenceIndividual patient reportsPatient group reportsNo. of drugs
Definite 104 22 
Probable 55 20 additional drugs 
Possible 363 40 27 additional drugs 
Unlikely 64 9 additional drugs 
Total 586 46 78 
Levels of evidenceIndividual patient reportsPatient group reportsNo. of drugs
Definite 104 22 
Probable 55 20 additional drugs 
Possible 363 40 27 additional drugs 
Unlikely 64 9 additional drugs 
Total 586 46 78 

The 586 individual patients were reported in 344 articles. The 46 patient groups were reported in 43 articles. These 387 articles reported 78 drugs. In the column describing the number of drugs, each drug is listed only once according to its highest level of evidence. The analysis of all 387 articles is described, with their citation, in supplemental Table 3.

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