Differential diagnosis of thrombocytopenia and MAHA
| Major disorder . | Examples . |
|---|---|
| Autoimmune disorders | SLE, scleroderma, antiphospholipid antibody syndrome |
| Systemic infection | Viral (CMV, adenovirus, HSV), bacterial (meningococcus, pneumococcus), fungal (Aspergillus) |
| Systemic malignancy | DIC or tumor emboli syndrome |
| Vasculitis | |
| DIC | Sepsis, cancer |
| Pregnancy associated | HELLP, eclampsia, HUS |
| Drugs | Quinine, simvastatin, interferon, calcineurin inhibitors |
| Malignant hypertension | |
| HUS |
| Major disorder . | Examples . |
|---|---|
| Autoimmune disorders | SLE, scleroderma, antiphospholipid antibody syndrome |
| Systemic infection | Viral (CMV, adenovirus, HSV), bacterial (meningococcus, pneumococcus), fungal (Aspergillus) |
| Systemic malignancy | DIC or tumor emboli syndrome |
| Vasculitis | |
| DIC | Sepsis, cancer |
| Pregnancy associated | HELLP, eclampsia, HUS |
| Drugs | Quinine, simvastatin, interferon, calcineurin inhibitors |
| Malignant hypertension | |
| HUS |
CMV, cytomegalovirus; DIC, disseminated intravascular coagulation; HELLP, hemolysis, elevated liver enzymes, low platelets; HSV, herpes simplex virus; HUS, hemolytic uremic syndrome; SLE, systemic lupus erythematosus.