Secretion of platelet ATP induced by different agonists in patient III-7
| Agonist . | Released ATP (nmol/108 platelets) . | ||
|---|---|---|---|
| Patient III-7, experiment 1 . | Patient III-7, experiment 2 . | Normal range* . | |
| ADP (4 μM) | Undetectable | Undetectable | 0.02-0.98 (n = 96) |
| ADP (20 μM) | Undetectable | Undetectable | 0.04-0.61 (n = 59) |
| Collagen (2 μg/mL) | 0.46 | 0.47 | 0.17-0.93 (n = 62) |
| U46619 (0.5 μM) | 0.02 | 0.03 | 0.02-1.03 (n = 72) |
| TRAP-6 (10 μM) | Not done | 0.17 | 0.01-1.08 (n = 41) |
| Agonist . | Released ATP (nmol/108 platelets) . | ||
|---|---|---|---|
| Patient III-7, experiment 1 . | Patient III-7, experiment 2 . | Normal range* . | |
| ADP (4 μM) | Undetectable | Undetectable | 0.02-0.98 (n = 96) |
| ADP (20 μM) | Undetectable | Undetectable | 0.04-0.61 (n = 59) |
| Collagen (2 μg/mL) | 0.46 | 0.47 | 0.17-0.93 (n = 62) |
| U46619 (0.5 μM) | 0.02 | 0.03 | 0.02-1.03 (n = 72) |
| TRAP-6 (10 μM) | Not done | 0.17 | 0.01-1.08 (n = 41) |
PRP containing trisodium citrate as anticoagulant was stimulated by different agonists at the indicated concentrations.
TRAP-6, thrombin receptor activating peptide 6; U46619, thromboxane/prostaglandin endoperoxide analog 9,11-dideoxy-11,9-epoxymethano-prostaglandin F2.
The normal ranges are defined by the 2.5 and 97.5 percentiles of the distribution of values obtained in healthy subjects.