Frequencies and stability of MRD-PCR targets in childhood BCP-ALL and T-ALL
| Gene . | Rearrangement type . | Precursor-B-ALL . | T-ALL . | ||||
|---|---|---|---|---|---|---|---|
| Frequency . | Oligoclonality . | Stability . | Frequency . | Stability . | |||
| Monoclonal . | Oligoclonal . | ||||||
| IGH | VH-JH | 93% | 30-40% | 88% | 47% | 5% | NT |
| DH-JH | 20% | 50-60% | 57% | 38% | 23% | NT | |
| Total IGH | 98% | ∼40% | 85% | 44% | 23% | NT | |
| IGK | Vκ-Kde | 45% | 5-10% | 95% | 40% | 0% | NA |
| Intron RSS-Kde | 25% | 5-10% | 86% | 0% | 0% | NA | |
| Total Kde | 50% | 5-10% | 95% | 40% | 0% | NA | |
| TRB | Vβ-Jβ | 21% | 10-15% | 89% | 60% | 77% | 79% |
| Dβ-Jβ | 14% | 10-15% | 67% | 0% | 55% | 80% | |
| Total TRB | 33% | 10-15% | 81% | 43% | 92% | 80% | |
| TRG | Vγ-Jγ | 55% | ∼15% | 75% | 95% | 86% | |
| TRD | Vδ-Jδ or Dδ-Jδ1 | <1% | NA | NA | NA | 50% | 100% |
| Vδ2-Dδ3 or Dδ2-Dδ3 | 40% | 20-25% | 86% | 26% | 55% | 100% | |
| Total TRD | 40% | 20-25% | 86% | 26% | 55% | 100% | |
| TRD/A | Vδ2-Jα | 46% | ∼45% | 86% | 43% | NT | NT |
| Gene . | Rearrangement type . | Precursor-B-ALL . | T-ALL . | ||||
|---|---|---|---|---|---|---|---|
| Frequency . | Oligoclonality . | Stability . | Frequency . | Stability . | |||
| Monoclonal . | Oligoclonal . | ||||||
| IGH | VH-JH | 93% | 30-40% | 88% | 47% | 5% | NT |
| DH-JH | 20% | 50-60% | 57% | 38% | 23% | NT | |
| Total IGH | 98% | ∼40% | 85% | 44% | 23% | NT | |
| IGK | Vκ-Kde | 45% | 5-10% | 95% | 40% | 0% | NA |
| Intron RSS-Kde | 25% | 5-10% | 86% | 0% | 0% | NA | |
| Total Kde | 50% | 5-10% | 95% | 40% | 0% | NA | |
| TRB | Vβ-Jβ | 21% | 10-15% | 89% | 60% | 77% | 79% |
| Dβ-Jβ | 14% | 10-15% | 67% | 0% | 55% | 80% | |
| Total TRB | 33% | 10-15% | 81% | 43% | 92% | 80% | |
| TRG | Vγ-Jγ | 55% | ∼15% | 75% | 95% | 86% | |
| TRD | Vδ-Jδ or Dδ-Jδ1 | <1% | NA | NA | NA | 50% | 100% |
| Vδ2-Dδ3 or Dδ2-Dδ3 | 40% | 20-25% | 86% | 26% | 55% | 100% | |
| Total TRD | 40% | 20-25% | 86% | 26% | 55% | 100% | |
| TRD/A | Vδ2-Jα | 46% | ∼45% | 86% | 43% | NT | NT |
Table is based on the following references: 26 and 37,,,,,,,-45. NA, not applicable; NT, not tested.