Exploring the effect of center in the FrenchCoag database
| Centers . | N . | Kogenate . | Advate . | Kogenate – Advate . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| PUPs (n) . | Inhibitors (n) . | % . | PUPs (n) . | Inhibitors (n) . | % . | Absolute difference (%) . | 95% CI (%) . | |||
| All centers | 234 | 124 | 56 | 45 | 110 | 33 | 30 | 15 | 3 | 27 |
| Centers 1, 3, and 13* | 73 | 50 | 29 | 58 | 23 | 4 | 17 | 41 | 17 | 47 |
| All centers except 1, 3, and 13 | 161 | 74 | 27 | 36 | 87 | 29 | 33 | 3 | −11 | 18 |
| Centers . | N . | Kogenate . | Advate . | Kogenate – Advate . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| PUPs (n) . | Inhibitors (n) . | % . | PUPs (n) . | Inhibitors (n) . | % . | Absolute difference (%) . | 95% CI (%) . | |||
| All centers | 234 | 124 | 56 | 45 | 110 | 33 | 30 | 15 | 3 | 27 |
| Centers 1, 3, and 13* | 73 | 50 | 29 | 58 | 23 | 4 | 17 | 41 | 17 | 47 |
| All centers except 1, 3, and 13 | 161 | 74 | 27 | 36 | 87 | 29 | 33 | 3 | −11 | 18 |
Absolute difference was calculated as percentage for Kogenate minus percentage for Advate. A positive value indicates a higher rate with Kogenate. 95% CI was calculated as suggested by Newcombe.2 When the interval does not cross 0, the difference is significant.
Centers with >10 patients on Kogenate (product D) or Advate (product E) and inhibitor rate for Kogenate >50%.