Table 3 Factors associated with 5-year... | American Society of Hematology

Table 3

Factors associated with 5-year mortality: multivariate analysis

Factors	RR of mortality (95% CI)	P value compared with reference group	P value compared with second reference group
Conditioning regimen
No FLU + TBI*	1.0		<.01
FLU + TBI 450 cGy†	0.3 (0.1-0.6)	<.01
FLU + TBI 300 cGy	0.1 (0.03-0.2)	<.01	<.01
Hematopoietic stem cell source
HLA-matched TCD URD BM*	1.0
1-Ag HLA-mismatched TCD URD BM	0.3 (0.1-0.8)	.02
1-Ag HLA-mismatched TCD RD BM	0.3 (0.03-2.1)	.21
URD UCB	2.0 (0.9-4.4)	.08
Age at transplant
<10 y*	1.0
10-17 y	2.2 (1.1-4.5)	.03
≥18 y	2.7 (1.2-5.8)	.01
Opportunistic infections before HCT
No*	1.0
Yes	3.5 (1.6-7.5)	<.01
Transfusions before HCT
None*	1.0
Any	2.3 (1.0-5.6)	.06
CMV serostatus
Patient negative/donor negative*	1.0
Patient negative/donor positive	1.7 (0.8-3.9)	.19
Patient positive	2.3 (1.2-4.5)	.02

Factors	RR of mortality (95% CI)	P value compared with reference group	P value compared with second reference group
Conditioning regimen
No FLU + TBI*	1.0		<.01
FLU + TBI 450 cGy†	0.3 (0.1-0.6)	<.01
FLU + TBI 300 cGy	0.1 (0.03-0.2)	<.01	<.01
Hematopoietic stem cell source
HLA-matched TCD URD BM*	1.0
1-Ag HLA-mismatched TCD URD BM	0.3 (0.1-0.8)	.02
1-Ag HLA-mismatched TCD RD BM	0.3 (0.03-2.1)	.21
URD UCB	2.0 (0.9-4.4)	.08
Age at transplant
<10 y*	1.0
10-17 y	2.2 (1.1-4.5)	.03
≥18 y	2.7 (1.2-5.8)	.01
Opportunistic infections before HCT
No*	1.0
Yes	3.5 (1.6-7.5)	<.01
Transfusions before HCT
None*	1.0
Any	2.3 (1.0-5.6)	.06
CMV serostatus
Patient negative/donor negative*	1.0
Patient negative/donor positive	1.7 (0.8-3.9)	.19
Patient positive	2.3 (1.2-4.5)	.02

RD, related donor.

Reference group.

Second reference group.