Multiple regression analysis on risk of treatment failure as defined by GRFS (boldface denotes statistical significance
| Factors . | Strata . | n . | RR of GRFS (95% CI) . | P value . |
|---|---|---|---|---|
| Conditioning | MA | 494 | 1.0 | |
| RIC | 413 | 0.9 (0.8-1.1) | .48 | |
| Donor type | Marrow MSD (age <21) | 43 | 1.0 | Reference |
| Marrow MSD (age 21+) | 10 | 1.8 (0.2-3.5) | .73 | |
| PBSC MSD (age <21) | 9 | 1.0 (0.3-3.5) | .98 | |
| PBSC MSD (age 21+) | 260 | 3.6 (2.1-6.4) | <.01 | |
| Marrow/PBSC URD (age <21) | 13 | 1.9 (0.8-4.5) | .16 | |
| Marrow/PBSC URD (age 21+) | 60 | 3.6 (1.9-6.7) | <.01 | |
| UCB (age <21) | 155 | 1.8 (1.0-3.3) | .04 | |
| UCB (age 21+) | 357 | 3.6 (2.0-6.3) | <.01 | |
| Disease risk | Standard risk | 590 | 1.0 | |
| High risk | 317 | 1.3 (1.0-1.5) | <.01 | |
| Year of HCT | 2000-2007 | 558 | 1.0 | |
| 2008-2012 | 349 | 0.8 (0.6-0.9) | <.01 | |
| HCT-CI | Score of 0 | 235 | 1.0 | .23 |
| Score of 1-2 | 193 | 1.0 (0.8-1.3) | ||
| Score of 3+ | 267 | 1.2 (1.0-1.5) | ||
| Missing | 212 | 1.1 (0.9-1.5) |
| Factors . | Strata . | n . | RR of GRFS (95% CI) . | P value . |
|---|---|---|---|---|
| Conditioning | MA | 494 | 1.0 | |
| RIC | 413 | 0.9 (0.8-1.1) | .48 | |
| Donor type | Marrow MSD (age <21) | 43 | 1.0 | Reference |
| Marrow MSD (age 21+) | 10 | 1.8 (0.2-3.5) | .73 | |
| PBSC MSD (age <21) | 9 | 1.0 (0.3-3.5) | .98 | |
| PBSC MSD (age 21+) | 260 | 3.6 (2.1-6.4) | <.01 | |
| Marrow/PBSC URD (age <21) | 13 | 1.9 (0.8-4.5) | .16 | |
| Marrow/PBSC URD (age 21+) | 60 | 3.6 (1.9-6.7) | <.01 | |
| UCB (age <21) | 155 | 1.8 (1.0-3.3) | .04 | |
| UCB (age 21+) | 357 | 3.6 (2.0-6.3) | <.01 | |
| Disease risk | Standard risk | 590 | 1.0 | |
| High risk | 317 | 1.3 (1.0-1.5) | <.01 | |
| Year of HCT | 2000-2007 | 558 | 1.0 | |
| 2008-2012 | 349 | 0.8 (0.6-0.9) | <.01 | |
| HCT-CI | Score of 0 | 235 | 1.0 | .23 |
| Score of 1-2 | 193 | 1.0 (0.8-1.3) | ||
| Score of 3+ | 267 | 1.2 (1.0-1.5) | ||
| Missing | 212 | 1.1 (0.9-1.5) |
HCT-CI, hematopoietic cell transplant comorbidity index.