ROC analysis to FVIII activity and inhibitor concentrations to predict PR within 21 days with steroids alone
| Threshold . | AUC (CI) . | Sensitivity (CI) . | Specificity (CI) . | LR . | PPV . | NPV . |
|---|---|---|---|---|---|---|
| FVIII activity, IU/dL | 0.75 (0.64-0.86) | |||||
| ≥1 | 0.84 (0.64-0.95) | 0.56 (0.44-0.67) | 1.9 | 0.38 | 0.91 | |
| >2 | 0.72 (0.51-0.88) | 0.73 (0.61-0.82) | 2.6 | 0.46 | 0.89 | |
| >6 | 0.32 (0.15-0.54) | 0.92 (0.84-0.97) | 4.1 | 0.57 | 0.81 | |
| >18 | 0.08 (0.01-0.26) | 0.99 (0.93-1.00) | 6.2 | 0.67 | 0.77 | |
| Inhibitor concentration, BU/mL | 0.78 (0.67-0.89) | |||||
| <2 | 0.20 (0.07-0.41) | 0.97 (0.91-1.00) | 7.7 | 0.80 | 0.78 | |
| <5 | 0.52 (0.31-0.72) | 0.90 (0.81-0.95) | 5.0 | 0.62 | 0.85 | |
| <20 | 0.84 (0.64-0.95) | 0.57 (0.45-0.68) | 2.0 | 0.40 | 0.88 | |
| <100 | 0.92 (0.74-0.99) | 0.26 (0.17-0.37) | 1.2 | 0.29 | 0.91 |
| Threshold . | AUC (CI) . | Sensitivity (CI) . | Specificity (CI) . | LR . | PPV . | NPV . |
|---|---|---|---|---|---|---|
| FVIII activity, IU/dL | 0.75 (0.64-0.86) | |||||
| ≥1 | 0.84 (0.64-0.95) | 0.56 (0.44-0.67) | 1.9 | 0.38 | 0.91 | |
| >2 | 0.72 (0.51-0.88) | 0.73 (0.61-0.82) | 2.6 | 0.46 | 0.89 | |
| >6 | 0.32 (0.15-0.54) | 0.92 (0.84-0.97) | 4.1 | 0.57 | 0.81 | |
| >18 | 0.08 (0.01-0.26) | 0.99 (0.93-1.00) | 6.2 | 0.67 | 0.77 | |
| Inhibitor concentration, BU/mL | 0.78 (0.67-0.89) | |||||
| <2 | 0.20 (0.07-0.41) | 0.97 (0.91-1.00) | 7.7 | 0.80 | 0.78 | |
| <5 | 0.52 (0.31-0.72) | 0.90 (0.81-0.95) | 5.0 | 0.62 | 0.85 | |
| <20 | 0.84 (0.64-0.95) | 0.57 (0.45-0.68) | 2.0 | 0.40 | 0.88 | |
| <100 | 0.92 (0.74-0.99) | 0.26 (0.17-0.37) | 1.2 | 0.29 | 0.91 |
LR, likelihood ratio; NPV negative predictive value; PPV, positive predictive value.