Patient characteristics and outcomes
| . | Patients . | 5-y EFS (%) . | P . | 5-y OS (%) . | P . |
|---|---|---|---|---|---|
| All patients | 490 | 43.7 ± 2.7 | 49.0 ± 2.7 | ||
| Median age, y (range) | 1.53 (0.01-16.47) | .266 | .491 | ||
| <1.53, n (%) | 245 (50.0) | 41.5 ± 3.7 | 48.1 ± 3.7 | ||
| ≥1.53, n (%) | 245 (50.0) | 46.0 ± 3.8 | 49.8 ± 3.9 | ||
| Sex | .637 | .621 | |||
| Female, n (%) | 247 (50.4) | 45.4 ± 3.8 | 50.3 ± 3.8 | ||
| Male, n (%) | 243 (49.6) | 42.0 ± 3.7 | 47.6 ± 3.8 | ||
| Year of diagnosis | .037 | .003 | |||
| 1989-1999, n (%) | 165 (33.7) | 38.6 ± 3.9 | 41.0 ± 3.9 | ||
| 2000-2009, n (%) | 325 (66.3) | 46.5 ± 3.5 | 53.0 ± 3.6 | ||
| Median WBC count, × 109/L (range)* | 12.0 (0.6-188.0) | .548 | .726 | ||
| <20 × 109/L, n (%) | 356 (73.9) | 44.5 ± 3.1 | 49.5 ± 3.1 | ||
| 20-100 × 109/L, n (%) | 121 (25.1) | 43.0 ± 5.3 | 48.4 ± 5.6 | ||
| ≥100 × 109/L, n (%) | 5 (1.0) | 20.0 ± 12.6¶ | 30.0 ± 17.7 | ||
| Median PB blasts, % (range)† | 12 (0-93) | .594 | .724 | ||
| Less than median, n (%) | 206 | 44.8 ± 4.1 | 48.4 ± 4.2 | ||
| At least median, n (%) | 224 | 44.3 ± 3.8 | 49.0 ± 3.9 | ||
| Median BM blasts, % (range)‡ | 41 (0-98) | .120 | .270 | ||
| Less than median, n (%) | 213 | 48.1 ± 4.1 | 52.2 ± 4.1 | ||
| At least median, n (%) | 215 | 40.2 ± 4.1 | 45.6 ± 4.3 | ||
| CNS involvement§ | .740 | .264 | |||
| Yes, n (%) | 23 (4.9) | 38.6 ± 10.1 | 38.3 ± 10.0 | ||
| No, n (%) | 445 (95.1) | 44.4 ± 2.8 | 50.0 ± 2.9 | ||
| Cytogenetics | .965 | .753 | |||
| Yes, n (%) | 372 (75.9) | 44.0 ± 3.1 | 48.7 ± 3.2 | ||
| No, n (%) | 118 (24.1) | 42.9 ± 5.0 | 50.0 ± 5.2 |
| . | Patients . | 5-y EFS (%) . | P . | 5-y OS (%) . | P . |
|---|---|---|---|---|---|
| All patients | 490 | 43.7 ± 2.7 | 49.0 ± 2.7 | ||
| Median age, y (range) | 1.53 (0.01-16.47) | .266 | .491 | ||
| <1.53, n (%) | 245 (50.0) | 41.5 ± 3.7 | 48.1 ± 3.7 | ||
| ≥1.53, n (%) | 245 (50.0) | 46.0 ± 3.8 | 49.8 ± 3.9 | ||
| Sex | .637 | .621 | |||
| Female, n (%) | 247 (50.4) | 45.4 ± 3.8 | 50.3 ± 3.8 | ||
| Male, n (%) | 243 (49.6) | 42.0 ± 3.7 | 47.6 ± 3.8 | ||
| Year of diagnosis | .037 | .003 | |||
| 1989-1999, n (%) | 165 (33.7) | 38.6 ± 3.9 | 41.0 ± 3.9 | ||
| 2000-2009, n (%) | 325 (66.3) | 46.5 ± 3.5 | 53.0 ± 3.6 | ||
| Median WBC count, × 109/L (range)* | 12.0 (0.6-188.0) | .548 | .726 | ||
| <20 × 109/L, n (%) | 356 (73.9) | 44.5 ± 3.1 | 49.5 ± 3.1 | ||
| 20-100 × 109/L, n (%) | 121 (25.1) | 43.0 ± 5.3 | 48.4 ± 5.6 | ||
| ≥100 × 109/L, n (%) | 5 (1.0) | 20.0 ± 12.6¶ | 30.0 ± 17.7 | ||
| Median PB blasts, % (range)† | 12 (0-93) | .594 | .724 | ||
| Less than median, n (%) | 206 | 44.8 ± 4.1 | 48.4 ± 4.2 | ||
| At least median, n (%) | 224 | 44.3 ± 3.8 | 49.0 ± 3.9 | ||
| Median BM blasts, % (range)‡ | 41 (0-98) | .120 | .270 | ||
| Less than median, n (%) | 213 | 48.1 ± 4.1 | 52.2 ± 4.1 | ||
| At least median, n (%) | 215 | 40.2 ± 4.1 | 45.6 ± 4.3 | ||
| CNS involvement§ | .740 | .264 | |||
| Yes, n (%) | 23 (4.9) | 38.6 ± 10.1 | 38.3 ± 10.0 | ||
| No, n (%) | 445 (95.1) | 44.4 ± 2.8 | 50.0 ± 2.9 | ||
| Cytogenetics | .965 | .753 | |||
| Yes, n (%) | 372 (75.9) | 44.0 ± 3.1 | 48.7 ± 3.2 | ||
| No, n (%) | 118 (24.1) | 42.9 ± 5.0 | 50.0 ± 5.2 |