Multivariate risk factor analysis for TRM in the first 12 mo after ASCT
| Risk factor . | P . | HR . | 95% CI for HR . |
|---|---|---|---|
| Low 3-IS level days 0 to 10 (n = 75) | .013 | 3.895 | 1.329-11.412 |
| Patient’s age (>50 y, n = 81) | .078 | 2.499 | 0.903-6.916 |
| Donor (MUD, n = 94) | .861 | 1.096 | 0.394-3.046 |
| Stage of underlying disease (advanced, n = 45) | .623 | 1.250 | 0.514-3.040 |
| Conditioning (RIC, n = 112) | .943 | 0.973 | 0.464-2.041 |
| Length of neutropenia (median 21 d, range 0-40 d) | .636 | 1.316 | 0.422-4.103 |
| Duration of antibiotic therapy (median 19 d, range 0-40 d) | .351 | 0.627 | 0.234-1.674 |
| Risk factor . | P . | HR . | 95% CI for HR . |
|---|---|---|---|
| Low 3-IS level days 0 to 10 (n = 75) | .013 | 3.895 | 1.329-11.412 |
| Patient’s age (>50 y, n = 81) | .078 | 2.499 | 0.903-6.916 |
| Donor (MUD, n = 94) | .861 | 1.096 | 0.394-3.046 |
| Stage of underlying disease (advanced, n = 45) | .623 | 1.250 | 0.514-3.040 |
| Conditioning (RIC, n = 112) | .943 | 0.973 | 0.464-2.041 |
| Length of neutropenia (median 21 d, range 0-40 d) | .636 | 1.316 | 0.422-4.103 |
| Duration of antibiotic therapy (median 19 d, range 0-40 d) | .351 | 0.627 | 0.234-1.674 |
Low urinary 3-IS levels between days 0 and 10 after ASCT were significantly associated with increased risk of TRM (n = 130). In the table, numbers for high-risk groups are indicated for categorical variables. Significance level <.05.
CI, confidence interval; HR, hazard ratio; MUD, matched unrelated donor; RIC, reduced intensity conditioning.