Statistical comparison and cut point calculation to differentiate between pathogenic and nonpathogenic FVIII-specific IgG1
| Comparison . | Adjusted P . | Sensitivity . | Specificity . | Cut point KA [M−1] . |
|---|---|---|---|---|
| KA HA-INH IgG1 > KA HA-noINH IgG1 | <.0001 | 0.875 | 0.987 | 1.3 × 109 |
| KA Acqu-HA IgG1 > KA Healthy IgG1 | <.0001 | 0.895 | 1.000 | 2.5 × 109 |
| Comparison . | Adjusted P . | Sensitivity . | Specificity . | Cut point KA [M−1] . |
|---|---|---|---|---|
| KA HA-INH IgG1 > KA HA-noINH IgG1 | <.0001 | 0.875 | 0.987 | 1.3 × 109 |
| KA Acqu-HA IgG1 > KA Healthy IgG1 | <.0001 | 0.895 | 1.000 | 2.5 × 109 |
Statistical cut point calculation for apparent affinities of FVIII-specific IgG1, comparing congenital hemophilia A patients with (HA-INH) and without (HA-noINH) FVIII inhibitors, and comparing patients with acquired hemophilia A (Acqu-HA) with healthy individuals (Healthy), using the Youden index approach as described in “Materials and methods.”