Multivariate analysis for OS, EFS, and aGVHD and cGVHD
| . | OS . | EFS . | ||
|---|---|---|---|---|
| HR (95% CI) . | P . | HR (95% CI) . | P . | |
| Age | ||||
| <10 y | 1.00 | 1.00 | .285 | |
| >10 y | 2.66 (1.19-5.93) | .017 | 1.44 (0.74-2.79) | |
| Calendar year | ||||
| Continuous, effect for +1 y | 0.91 (0.84-0.98) | .008 | 0.93 (0.88-0.99) | .017 |
| HLA | ||||
| Matched | 1.00* | 1.00 | ||
| Mismatched | 3.70 (1.51-9.10) | .004 | 2.54 (1.15-5.62) | .021 |
| . | OS . | EFS . | ||
|---|---|---|---|---|
| HR (95% CI) . | P . | HR (95% CI) . | P . | |
| Age | ||||
| <10 y | 1.00 | 1.00 | .285 | |
| >10 y | 2.66 (1.19-5.93) | .017 | 1.44 (0.74-2.79) | |
| Calendar year | ||||
| Continuous, effect for +1 y | 0.91 (0.84-0.98) | .008 | 0.93 (0.88-0.99) | .017 |
| HLA | ||||
| Matched | 1.00* | 1.00 | ||
| Mismatched | 3.70 (1.51-9.10) | .004 | 2.54 (1.15-5.62) | .021 |
| . | aGVHD . | . | cGVHD . | |
|---|---|---|---|---|
| . | HR (95% CI) . | P . | HR (95% CI) . | P . |
| Age | ||||
| <10 y | 1.00 | 1.00 | ||
| >10 y | 1.39 (0.66-2.92) | .390 | 2.83 (1.16-6.92) | .022 |
| HLA | ||||
| Matched related | 1.00 | — | ||
| Matched unrelated | 3.13 (1.43-6.86) | .004 | — | |
| Mismatched | 1.42 (0.38-5.33) | .607 | — | |
| Source of cells | ||||
| BM or CB | — | 1.00 | ||
| PB | — | 2.18 (0.90-5.28) | .084 | |
| GVHD prophylaxis | ||||
| No/only CSA | 1.00 | — | ||
| CSA + MTX | 0.33 (0.15-0.74) | .007 | — | |
| . | aGVHD . | . | cGVHD . | |
|---|---|---|---|---|
| . | HR (95% CI) . | P . | HR (95% CI) . | P . |
| Age | ||||
| <10 y | 1.00 | 1.00 | ||
| >10 y | 1.39 (0.66-2.92) | .390 | 2.83 (1.16-6.92) | .022 |
| HLA | ||||
| Matched related | 1.00 | — | ||
| Matched unrelated | 3.13 (1.43-6.86) | .004 | — | |
| Mismatched | 1.42 (0.38-5.33) | .607 | — | |
| Source of cells | ||||
| BM or CB | — | 1.00 | ||
| PB | — | 2.18 (0.90-5.28) | .084 | |
| GVHD prophylaxis | ||||
| No/only CSA | 1.00 | — | ||
| CSA + MTX | 0.33 (0.15-0.74) | .007 | — | |
HR, hazard ratio.
Given the nonrelevant difference between matched-related donor and MUD in univariate analysis, these 2 categories were lumped together in the matched category in the multivariate analysis.