Multivariate analysis of risk factors for 2-y outcome after allogeneic HSCT
| . | P . | HR . | 95% CI . | |
|---|---|---|---|---|
| Lower . | Upper . | |||
| CIR | ||||
| FLT3-ITD vs FLT3wt | .0003 | 2.23 | 1.44 | 3.46 |
| NPM1mut vs NPM1wt | .47 | 0.85 | 0.56 | 1.31 |
| RIC vs MAC | .032 | 1.25 | 0.81 | 1.93 |
| age > median | .21 | 1.31 | 0.86 | 1.99 |
| UD vs HLA id | .18 | 0.77 | 0.52 | 1.13 |
| Interval CR1 to HSCT > median | .94 | 0.99 | 0.67 | 1.45 |
| Year of HSCT > median | .32 | 0.81 | 0.54 | 1.22 |
| Number of induction courses for CR1 > 1 | .04 | 1.50 | 1.02 | 2.22 |
| NRM | ||||
| FLT3-ITD vs FLT3wt | .37 | 1.28 | 0.74 | 2.19 |
| NPM1mut vs NPM1wt | .50 | 0.83 | 0.49 | 1.42 |
| RIC vs MAC | .04 | 0.57 | 0.34 | 0.97 |
| age > median | .00001 | 3.42 | 1.98 | 5.91 |
| UD vs HLA id | .10 | 1.47 | 0.93 | 2.31 |
| Interval CR1 to HSCT > median | .02 | 1.80 | 1.11 | 2.91 |
| Year of HSCT > median | .41 | 0.81 | 0.48 | 1.35 |
| Number of induction courses for CR1 > 1 | .23 | 1.36 | 0.82 | 2.24 |
| OS | ||||
| FLT3-ITD vs FLT3wt | .001 | 1.85 | 1.29 | 2.66 |
| NPM1mut vs NPM1wt | .24 | 0.81 | 0.57 | 1.15 |
| RIC vs MAC | .53 | 0.89 | 0.62 | 1.28 |
| age > median | .0000005 | 2.54 | 1.77 | 3.66 |
| UD vs HLA id | .41 | 1.14 | 0.84 | 1.56 |
| Interval CR1 to HSCT > median | .08 | 1.33 | 0.96 | 1.83 |
| Year of HSCT > median | .41 | 0.86 | 0.60 | 1.23 |
| Number of induction courses for CR1 > 1 | .04 | 1.37 | 0.99 | 1.91 |
| LFS | ||||
| FLT3-ITD vs FLT3wt | .001 | 1.77 | 1.27 | 2.48 |
| NPM1mut vs NPM1wt | .32 | 0.84 | 0.61 | 1.18 |
| RIC vs MAC | .60 | 0.91 | 0.65 | 1.28 |
| age > median | .0002 | 1.90 | 1.36 | 2.66 |
| UD vs HLA id | 1.00 | 1.00 | 0.75 | 1.34 |
| Interval CR1 to HSCT > median | .14 | 1.25 | 0.93 | 1.67 |
| Year of HSCT > median | .23 | 0.82 | 0.60 | 1.13 |
| Number of induction courses for CR1 > 1 | .02 | 1.43 | 1.06 | 1.95 |
| . | P . | HR . | 95% CI . | |
|---|---|---|---|---|
| Lower . | Upper . | |||
| CIR | ||||
| FLT3-ITD vs FLT3wt | .0003 | 2.23 | 1.44 | 3.46 |
| NPM1mut vs NPM1wt | .47 | 0.85 | 0.56 | 1.31 |
| RIC vs MAC | .032 | 1.25 | 0.81 | 1.93 |
| age > median | .21 | 1.31 | 0.86 | 1.99 |
| UD vs HLA id | .18 | 0.77 | 0.52 | 1.13 |
| Interval CR1 to HSCT > median | .94 | 0.99 | 0.67 | 1.45 |
| Year of HSCT > median | .32 | 0.81 | 0.54 | 1.22 |
| Number of induction courses for CR1 > 1 | .04 | 1.50 | 1.02 | 2.22 |
| NRM | ||||
| FLT3-ITD vs FLT3wt | .37 | 1.28 | 0.74 | 2.19 |
| NPM1mut vs NPM1wt | .50 | 0.83 | 0.49 | 1.42 |
| RIC vs MAC | .04 | 0.57 | 0.34 | 0.97 |
| age > median | .00001 | 3.42 | 1.98 | 5.91 |
| UD vs HLA id | .10 | 1.47 | 0.93 | 2.31 |
| Interval CR1 to HSCT > median | .02 | 1.80 | 1.11 | 2.91 |
| Year of HSCT > median | .41 | 0.81 | 0.48 | 1.35 |
| Number of induction courses for CR1 > 1 | .23 | 1.36 | 0.82 | 2.24 |
| OS | ||||
| FLT3-ITD vs FLT3wt | .001 | 1.85 | 1.29 | 2.66 |
| NPM1mut vs NPM1wt | .24 | 0.81 | 0.57 | 1.15 |
| RIC vs MAC | .53 | 0.89 | 0.62 | 1.28 |
| age > median | .0000005 | 2.54 | 1.77 | 3.66 |
| UD vs HLA id | .41 | 1.14 | 0.84 | 1.56 |
| Interval CR1 to HSCT > median | .08 | 1.33 | 0.96 | 1.83 |
| Year of HSCT > median | .41 | 0.86 | 0.60 | 1.23 |
| Number of induction courses for CR1 > 1 | .04 | 1.37 | 0.99 | 1.91 |
| LFS | ||||
| FLT3-ITD vs FLT3wt | .001 | 1.77 | 1.27 | 2.48 |
| NPM1mut vs NPM1wt | .32 | 0.84 | 0.61 | 1.18 |
| RIC vs MAC | .60 | 0.91 | 0.65 | 1.28 |
| age > median | .0002 | 1.90 | 1.36 | 2.66 |
| UD vs HLA id | 1.00 | 1.00 | 0.75 | 1.34 |
| Interval CR1 to HSCT > median | .14 | 1.25 | 0.93 | 1.67 |
| Year of HSCT > median | .23 | 0.82 | 0.60 | 1.13 |
| Number of induction courses for CR1 > 1 | .02 | 1.43 | 1.06 | 1.95 |
HLA, human leukocyte antigen; MAC, myeloablative conditioning; MUD, matched unrelated donor.