Table 1

Recommendations from the European LeukemiaNet for the Management of CML

OptimalWarningFailure
Baseline  High-risk or CCA/Ph+ (major route)  
3 mo BCR/ABL1 <10% and/or Ph+ < 35% BCR/ABL1 >10% and/or Ph+ 36%-95% No CHR and/or Ph+ >95% 
6 mo BCR/ABL1 <1% and/or Ph+ 0 BCR/ABL1 1%-10% and/or Ph+ 1%-35% BCR/ABL1 >10% and/or Ph+ >35% 
12 mo BCR/ABL1 <0.1% BCR/ABL1 >0.1%-1% BCR/ABL1 _1% and/or Ph+ >0 
Thereafter, at any time BCR/ABL1 <0.1% CCA/Ph− (−7, or del7q) Loss of CHR; loss of CCyR; *confirmed loss of MMR; mutations; CCA/Ph+ 
OptimalWarningFailure
Baseline  High-risk or CCA/Ph+ (major route)  
3 mo BCR/ABL1 <10% and/or Ph+ < 35% BCR/ABL1 >10% and/or Ph+ 36%-95% No CHR and/or Ph+ >95% 
6 mo BCR/ABL1 <1% and/or Ph+ 0 BCR/ABL1 1%-10% and/or Ph+ 1%-35% BCR/ABL1 >10% and/or Ph+ >35% 
12 mo BCR/ABL1 <0.1% BCR/ABL1 >0.1%-1% BCR/ABL1 _1% and/or Ph+ >0 
Thereafter, at any time BCR/ABL1 <0.1% CCA/Ph− (−7, or del7q) Loss of CHR; loss of CCyR; *confirmed loss of MMR; mutations; CCA/Ph+ 

MMR indicates BCR/ABL1 <0.1%; CCA/Ph+, clonal chromosomal abnormalities in Ph+ cells; CCA/Ph−, clonal chromosomal abnormalities in Ph− cells.

*

Loss of MMR should be confirmed in 2 consecutive quantitative RT-PCR tests, of which one has a BCR/ABL1 transcripts level >1%.

Monitoring is performed by metaphase cytogenetics on bone marrow aspirate sample and/or by quantitative RT-PCR for BCR/ABL1 transcript levels on blood samples.

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