Cox proportional hazard regression analysis between ADAMTS13 quartiles and stroke
| ADAMTS13 level . | Mean ADAMTS13 activity (95% CI) . | Number of cases/Total number at risk . | Absolute risk (%) . | Model 1 HR (95% CI) . | Model 2 HR (95% CI) . |
|---|---|---|---|---|---|
| All strokes (N = 461) | |||||
| Quartile 1 | 70.3 (69.8-70.8) | 163/1486 | 11.0 | 1.52 (1.15-2.02) | 1.49 (1.12-2.00) |
| Quartile 2 | 86.3 (86.2-86.5) | 108/1485 | 7.2 | 1.10 (0.82-1.47) | 1.08 (0.80-1.45) |
| Quartile 3 | 96.6 (96.4-96.7) | 111/1485 | 7.5 | 1.18 (0.88-1.58) | 1.17 (0.88-1.57) |
| Quartile 4 | 114.4 (113.8-114.9) | 79/1485 | 5.3 | 1 (ref) | 1 (ref) |
| Per SD decrease | 1.13 (1.02-1.24) | 1.12 (1.01-1.24) | |||
| Ischemic strokes (N = 306) | |||||
| Quartile 1 | 70.3 (69.8-70.8) | 109/1486 | 7.3 | 1.61 (1.15-2.26) | 1.65 (1.16-2.32) |
| Quartile 2 | 86.3 (86.2-86.5) | 70/1485 | 4.7 | 1.07 (0.75-1.53) | 1.08 (0.75-1.54) |
| Quartile 3 | 96.6 (96.4-96.7) | 71/1485 | 4.8 | 1.12 (0.79-1.60) | 1.13 (0.80-1.62) |
| Quartile 4 | 114.4 (113.8-114.9) | 56/1485 | 3.8 | 1 (ref) | 1 (ref) |
| Per SD decrease | 1.18 (1.04-1.33) | 1.19 (1.05-1.34) | |||
| TIA (N = 315) | |||||
| Quartile 1 | 70.3 (69.8-70.8) | 101/1486 | 6.8 | 1.55 (1.11-2.18) | 1.64 (1.17-2.31) |
| Quartile 2 | 86.3 (86.2-86.5) | 78/1485 | 5.3 | 1.20 (0.85-1.69) | 1.25 (0.89-1.76) |
| Quartile 3 | 96.6 (96.4-96.7) | 77/1485 | 5.2 | 1.19 (0.84-1.67) | 1.21 (0.86-1.71) |
| Quartile 4 | 114.4 (113.8-114.9) | 59/1485 | 4.0 | 1 (ref) | 1 (ref) |
| Per SD decrease | 1.17 (1.03-1.24) | 1.19 (1.05-1.34) | |||
| Any cerebrovascular event (N = 776) | |||||
| Quartile 1 | 70.3 (69.8-70.8) | 264/1486 | 17.8 | 1.54 (1.24-1.91) | 1.56 (1.25-1.94) |
| Quartile 2 | 86.3 (86.2-86.5) | 186/1485 | 12.5 | 1.14 (0.91-1.42) | 1.15 (0.92-1.44) |
| Quartile 3 | 96.6 (96.4-96.7) | 188/1485 | 12.7 | 1.18 (0.95-1.48) | 1.19 (0.95-1.48) |
| Quartile 4 | 114.4 (113.8-114.9) | 138/1485 | 9.3 | 1 (ref) | 1 (ref) |
| Per SD decrease | 1.14 (1.06-1.23) | 1.15 (1.06-1.24) |
| ADAMTS13 level . | Mean ADAMTS13 activity (95% CI) . | Number of cases/Total number at risk . | Absolute risk (%) . | Model 1 HR (95% CI) . | Model 2 HR (95% CI) . |
|---|---|---|---|---|---|
| All strokes (N = 461) | |||||
| Quartile 1 | 70.3 (69.8-70.8) | 163/1486 | 11.0 | 1.52 (1.15-2.02) | 1.49 (1.12-2.00) |
| Quartile 2 | 86.3 (86.2-86.5) | 108/1485 | 7.2 | 1.10 (0.82-1.47) | 1.08 (0.80-1.45) |
| Quartile 3 | 96.6 (96.4-96.7) | 111/1485 | 7.5 | 1.18 (0.88-1.58) | 1.17 (0.88-1.57) |
| Quartile 4 | 114.4 (113.8-114.9) | 79/1485 | 5.3 | 1 (ref) | 1 (ref) |
| Per SD decrease | 1.13 (1.02-1.24) | 1.12 (1.01-1.24) | |||
| Ischemic strokes (N = 306) | |||||
| Quartile 1 | 70.3 (69.8-70.8) | 109/1486 | 7.3 | 1.61 (1.15-2.26) | 1.65 (1.16-2.32) |
| Quartile 2 | 86.3 (86.2-86.5) | 70/1485 | 4.7 | 1.07 (0.75-1.53) | 1.08 (0.75-1.54) |
| Quartile 3 | 96.6 (96.4-96.7) | 71/1485 | 4.8 | 1.12 (0.79-1.60) | 1.13 (0.80-1.62) |
| Quartile 4 | 114.4 (113.8-114.9) | 56/1485 | 3.8 | 1 (ref) | 1 (ref) |
| Per SD decrease | 1.18 (1.04-1.33) | 1.19 (1.05-1.34) | |||
| TIA (N = 315) | |||||
| Quartile 1 | 70.3 (69.8-70.8) | 101/1486 | 6.8 | 1.55 (1.11-2.18) | 1.64 (1.17-2.31) |
| Quartile 2 | 86.3 (86.2-86.5) | 78/1485 | 5.3 | 1.20 (0.85-1.69) | 1.25 (0.89-1.76) |
| Quartile 3 | 96.6 (96.4-96.7) | 77/1485 | 5.2 | 1.19 (0.84-1.67) | 1.21 (0.86-1.71) |
| Quartile 4 | 114.4 (113.8-114.9) | 59/1485 | 4.0 | 1 (ref) | 1 (ref) |
| Per SD decrease | 1.17 (1.03-1.24) | 1.19 (1.05-1.34) | |||
| Any cerebrovascular event (N = 776) | |||||
| Quartile 1 | 70.3 (69.8-70.8) | 264/1486 | 17.8 | 1.54 (1.24-1.91) | 1.56 (1.25-1.94) |
| Quartile 2 | 86.3 (86.2-86.5) | 186/1485 | 12.5 | 1.14 (0.91-1.42) | 1.15 (0.92-1.44) |
| Quartile 3 | 96.6 (96.4-96.7) | 188/1485 | 12.7 | 1.18 (0.95-1.48) | 1.19 (0.95-1.48) |
| Quartile 4 | 114.4 (113.8-114.9) | 138/1485 | 9.3 | 1 (ref) | 1 (ref) |
| Per SD decrease | 1.14 (1.06-1.23) | 1.15 (1.06-1.24) |
Model 1 adjusted for age and sex. Model 2 additionally adjusted for antithrombotic medication, antihypertensive drugs, diabetes mellitus, lipid-reducing agents, BMI, smoking, total cholesterol, HDL cholesterol, systolic blood pressure, and diastolic blood pressure. “All strokes” indicates ischemic, hemorrhagic, and unspecified strokes. Any cerebrovascular event indicates all strokes and TIA. Cutoff points (%) for quartiles were: ≤80.73%, 80.74-91.44%, 91.45-102.26%, and ≥102.27%.