Characteristics and risk of bias assessment for cohort studies on transfusion therapy in pregnant women with sickle cell disease
| Author (year), country, setting . | Single vs multicenter . | Design . | Years of study . | Inclusion criteria . | Risk of bias assessment (NOS) . | ||||
|---|---|---|---|---|---|---|---|---|---|
| Selection ★★★★ . | Comparability ★★ . | Outcome ★★★ . | Total/9 . | Risk of bias (1-3: high; 4-6: moderate; 7-9: low) . | |||||
| Morrison (1976)28 * | Single | Prospective cohort, matched retrospectively with historical controls | Apr. 1970 – Mar. 1974 | SCD | ★★ | — | ★ | 3 | High |
| United States | Apr 1965 – Mar. 1970 - Historical controls | ||||||||
| Tertiary care | |||||||||
| Miller (1981)26 | Single | Retrospective cohort with historical controls | 1978-1980 (PT) | SCD | ★★ | — | ★ | 3 | High |
| United States | 1974-1979 (ODT) Historical controls | ||||||||
| Tertiary care | |||||||||
| Cunningham (1983)19 | Single | Retrospective cohort with historical controls | 1973-1982 (PT) | SCD | ★★ | — | ★ | 3 | High |
| United States | 1955-1972 (ODT) | ||||||||
| Tertiary care | |||||||||
| Tuck (1987)30 | Multi | Retrospective cohort | 1978-1984 (PT) | SCD | ★ | — | — | 1 | High |
| United Kingdom | 1975-1981 (Un-transfused) | ||||||||
| Tertiary care | |||||||||
| Koshy (1991)15 † | Single | Retrospective cohort | 1986-1990 | SCD | ★ | — | ★ | 2 | High |
| United States | |||||||||
| Tertiary care | |||||||||
| Morrison (1991)27 | Single | Retrospective cohort with historical controls | Jan 1981-Dec 1990 | HbSS, HbSC | ★★ | — | ★ | 3 | High |
| United States | |||||||||
| Tertiary care | |||||||||
| Howard (1995)10 | Multi | Retrospective cohort | 1991-1993 | SCD | ★★ | — | ★★ | 4 | Moderate |
| United Kingdom | |||||||||
| Hospitals England &Wales | |||||||||
| El-Shafei (1995)18 | Single | Mixed retrospective and prospective cohort | May 1988 – Oct. 1994 (prospective) vs Nov. 1986 – Oct. 1988 (retrospective) | SCD | ★★ | — | ★ | 3 | High |
| Bahrain | |||||||||
| MoH Hospital | |||||||||
| Moussaoui (2002)29 | Single | Retrospective cohort | Not stated | HbSS | ★★ | — | — | 2 | High |
| Libreville, Gabon | |||||||||
| Not stated | |||||||||
| Gilli (2007)17 | Single | Retrospective cohort | 1994-2004 | HbSS, HbSC | ★★ | ★ | ★ | 4 | Moderate |
| Brazil | |||||||||
| Tertiary care | |||||||||
| Asma (2015)14 | Single | Retrospective cohort | 2000-2013 | SCD | ★ | — | ★ | 2 | High |
| Turkey | |||||||||
| Tertiary care | |||||||||
| Author (year), country, setting . | Single vs multicenter . | Design . | Years of study . | Inclusion criteria . | Risk of bias assessment (NOS) . | ||||
|---|---|---|---|---|---|---|---|---|---|
| Selection ★★★★ . | Comparability ★★ . | Outcome ★★★ . | Total/9 . | Risk of bias (1-3: high; 4-6: moderate; 7-9: low) . | |||||
| Morrison (1976)28 * | Single | Prospective cohort, matched retrospectively with historical controls | Apr. 1970 – Mar. 1974 | SCD | ★★ | — | ★ | 3 | High |
| United States | Apr 1965 – Mar. 1970 - Historical controls | ||||||||
| Tertiary care | |||||||||
| Miller (1981)26 | Single | Retrospective cohort with historical controls | 1978-1980 (PT) | SCD | ★★ | — | ★ | 3 | High |
| United States | 1974-1979 (ODT) Historical controls | ||||||||
| Tertiary care | |||||||||
| Cunningham (1983)19 | Single | Retrospective cohort with historical controls | 1973-1982 (PT) | SCD | ★★ | — | ★ | 3 | High |
| United States | 1955-1972 (ODT) | ||||||||
| Tertiary care | |||||||||
| Tuck (1987)30 | Multi | Retrospective cohort | 1978-1984 (PT) | SCD | ★ | — | — | 1 | High |
| United Kingdom | 1975-1981 (Un-transfused) | ||||||||
| Tertiary care | |||||||||
| Koshy (1991)15 † | Single | Retrospective cohort | 1986-1990 | SCD | ★ | — | ★ | 2 | High |
| United States | |||||||||
| Tertiary care | |||||||||
| Morrison (1991)27 | Single | Retrospective cohort with historical controls | Jan 1981-Dec 1990 | HbSS, HbSC | ★★ | — | ★ | 3 | High |
| United States | |||||||||
| Tertiary care | |||||||||
| Howard (1995)10 | Multi | Retrospective cohort | 1991-1993 | SCD | ★★ | — | ★★ | 4 | Moderate |
| United Kingdom | |||||||||
| Hospitals England &Wales | |||||||||
| El-Shafei (1995)18 | Single | Mixed retrospective and prospective cohort | May 1988 – Oct. 1994 (prospective) vs Nov. 1986 – Oct. 1988 (retrospective) | SCD | ★★ | — | ★ | 3 | High |
| Bahrain | |||||||||
| MoH Hospital | |||||||||
| Moussaoui (2002)29 | Single | Retrospective cohort | Not stated | HbSS | ★★ | — | — | 2 | High |
| Libreville, Gabon | |||||||||
| Not stated | |||||||||
| Gilli (2007)17 | Single | Retrospective cohort | 1994-2004 | HbSS, HbSC | ★★ | ★ | ★ | 4 | Moderate |
| Brazil | |||||||||
| Tertiary care | |||||||||
| Asma (2015)14 | Single | Retrospective cohort | 2000-2013 | SCD | ★ | — | ★ | 2 | High |
| Turkey | |||||||||
| Tertiary care | |||||||||