Characteristics and risk of bias assessment for RCT on transfusion therapy in pregnant women with sickle cell disease
| Author (year), country, setting . | Single vs multicenter . | Design . | Years of study . | Inclusion criteria . | Risk of bias assessment . |
|---|---|---|---|---|---|
| Koshy (1988)16 | Multi | RCT | Jan 1979 to Mar 1986 | HbSS <28 weeks GA | Selection bias: Unclear |
| United States | Only HbSS randomized | Excluded neurologic dysfunction, nephrotic syndrome, chronic renal failure, persistent liver disease, chronic lung disease, coagulopathy, or presence of multiple RBC antibodies | |||
| Tertiary care | 28 with HbSS not randomized; of those, 7 continued long-term PT initiated prior to study | Performance bias: High risk | |||
| Detection bias: Unclear | |||||
| Attrition bias: Low risk | |||||
| Reporting bias: Unclear risk | |||||
| Overall: High risk of bias |
| Author (year), country, setting . | Single vs multicenter . | Design . | Years of study . | Inclusion criteria . | Risk of bias assessment . |
|---|---|---|---|---|---|
| Koshy (1988)16 | Multi | RCT | Jan 1979 to Mar 1986 | HbSS <28 weeks GA | Selection bias: Unclear |
| United States | Only HbSS randomized | Excluded neurologic dysfunction, nephrotic syndrome, chronic renal failure, persistent liver disease, chronic lung disease, coagulopathy, or presence of multiple RBC antibodies | |||
| Tertiary care | 28 with HbSS not randomized; of those, 7 continued long-term PT initiated prior to study | Performance bias: High risk | |||
| Detection bias: Unclear | |||||
| Attrition bias: Low risk | |||||
| Reporting bias: Unclear risk | |||||
| Overall: High risk of bias |