Outcomes in cohort studies of prophylactic transfusion compared with on-demand transfusion in pregnant women with SCD (cohort studies)
| Group . | Outcomes . | Studies, n . | Study subject, n . | OR (95% CI) . | Significance (heterogeneity), P (I2) . |
|---|---|---|---|---|---|
| Maternal | Mortality | 714,15,18,26-29 | 955 | 0.23 (0.06-0.91) | .04 (20%) |
| Vaso-occlusive pain episodes | 1110,15,17-19,26-30 | 1219 | 0.26 (0.09-0.76) | .01 (90%) | |
| Pulmonary complications* | 910,15,17-19,26-28,30 | 1019 | 0.25 (0.09-0.72) | .01 (77%) | |
| Pulmonary infection | 518,19,26-28 | 792 | 0.26 (0.05-1.27) | .10 (83%) | |
| Pulmonary embolism | 319,26,28 | 237 | 0.07 (0.01-0.41) | <.01 (1%) | |
| Acute chest syndrome | 215,17 | 102 | 0.28 (0.06-1.26) | .10 (0%) | |
| Urinary tract infection | 315,29,30 | 149 | 1.09 (0.22-5.42) | .92 (61%) | |
| Pyelonephritis | 615,19,26-29 | 455 | 0.19 (0.07-0.51) | <.01 (34%) | |
| Endometritis | 226,29 | 80 | 0.76 (0.17-3.44) | .72 (40%) | |
| Preeclampsia | 610,14,15,17,26,29 | 282 | 1.01 (0.49-2.08) | .98 (0%) | |
| Fetal | Perinatal mortality | 810,15,18,19,26-28,30 | 1140 | 0.43 (0.19-0.99) | <.05 (58%) |
| Intrauterine fetal demise | 814,15,17,19,26,28-30 | 458 | 0.47 (0.17-1.33) | .15 (32%) | |
| Neonatal death | 515,19,26,28,30 | 374 | 0.26 (0.07-0.93) | .04 (0%) | |
| Small for gestational age/low birth weight | 1010,15,17-19,26-30 | 1187 | 0.71 (0.44-1.16) | .17 (35%) | |
| Preterm delivery | 910,15,17-19,27-30 | 1123 | 0.59 (0.37-0.96) | .03 (38%) |
| Group . | Outcomes . | Studies, n . | Study subject, n . | OR (95% CI) . | Significance (heterogeneity), P (I2) . |
|---|---|---|---|---|---|
| Maternal | Mortality | 714,15,18,26-29 | 955 | 0.23 (0.06-0.91) | .04 (20%) |
| Vaso-occlusive pain episodes | 1110,15,17-19,26-30 | 1219 | 0.26 (0.09-0.76) | .01 (90%) | |
| Pulmonary complications* | 910,15,17-19,26-28,30 | 1019 | 0.25 (0.09-0.72) | .01 (77%) | |
| Pulmonary infection | 518,19,26-28 | 792 | 0.26 (0.05-1.27) | .10 (83%) | |
| Pulmonary embolism | 319,26,28 | 237 | 0.07 (0.01-0.41) | <.01 (1%) | |
| Acute chest syndrome | 215,17 | 102 | 0.28 (0.06-1.26) | .10 (0%) | |
| Urinary tract infection | 315,29,30 | 149 | 1.09 (0.22-5.42) | .92 (61%) | |
| Pyelonephritis | 615,19,26-29 | 455 | 0.19 (0.07-0.51) | <.01 (34%) | |
| Endometritis | 226,29 | 80 | 0.76 (0.17-3.44) | .72 (40%) | |
| Preeclampsia | 610,14,15,17,26,29 | 282 | 1.01 (0.49-2.08) | .98 (0%) | |
| Fetal | Perinatal mortality | 810,15,18,19,26-28,30 | 1140 | 0.43 (0.19-0.99) | <.05 (58%) |
| Intrauterine fetal demise | 814,15,17,19,26,28-30 | 458 | 0.47 (0.17-1.33) | .15 (32%) | |
| Neonatal death | 515,19,26,28,30 | 374 | 0.26 (0.07-0.93) | .04 (0%) | |
| Small for gestational age/low birth weight | 1010,15,17-19,26-30 | 1187 | 0.71 (0.44-1.16) | .17 (35%) | |
| Preterm delivery | 910,15,17-19,27-30 | 1123 | 0.59 (0.37-0.96) | .03 (38%) |
Pulmonary complications (infections, infarctions, and/or embolism).