Baseline characteristics and initial platelet response to therapy
| Parameter . | Responders . | Nonresponders . | P . |
|---|---|---|---|
| Demographics | |||
| Median age (range) | 50.2 (18.9-79.8) | 51.9 (19.3-67.5) | .9394 |
| Males/females | 10/2 | 1/7 | .0045 |
| Median time from diagnosis to TT4, months | 60 (1-206) | 42 (3-215) | .8345 |
| Newly diagnosed or persistent ITP | 3 | 4 | .3563 |
| Chronic ITP | 9 | 4 | |
| Primary ITP | 9 | 6 | 1.0000 |
| Secondary ITP | SLE | SLE | |
| APS | APS | ||
| Crohns disease | |||
| 2 or less prior lines of therapy | 8 | 0 | .0047 |
| 3 or more prior lines of therapy | 4 | 8 | |
| Median BSA | 1.98 (1.65-2.39) | 1.70 (1.48-2.29) | .1878 |
| Median weight, kg | 80.(61-114) | 67 (48-105) | .2779 |
| Splenectomy, prior | 1 | 1 | |
| Platelets | |||
| Baseline, median ×109/L | 18.5 (4-35) | 16.0 (4-24) | .2114 |
| Day 7, median | 109.0 (1-322) | 45.0 (9-114) | .0861 |
| Day 14, median | 91.5 (6-413) | 25 (9-252) | .0566 |
| Day 21, median | 92.5 (14-393) | 27.5 (8-79) | .0051 |
| Day 28, median | 144.5 (22-337) | 18.5 (9-131) | .0021 |
| Day 60, median | 108 (23-316) | 20 (1-61) | .0008 |
| Patients with platelets >30 × 109/L, day 30 | 11 | 3 | .0181 |
| Patients with platelets >30 × 109/L, at day 60 | 11 | 1 | .0017 |
| Parameter . | Responders . | Nonresponders . | P . |
|---|---|---|---|
| Demographics | |||
| Median age (range) | 50.2 (18.9-79.8) | 51.9 (19.3-67.5) | .9394 |
| Males/females | 10/2 | 1/7 | .0045 |
| Median time from diagnosis to TT4, months | 60 (1-206) | 42 (3-215) | .8345 |
| Newly diagnosed or persistent ITP | 3 | 4 | .3563 |
| Chronic ITP | 9 | 4 | |
| Primary ITP | 9 | 6 | 1.0000 |
| Secondary ITP | SLE | SLE | |
| APS | APS | ||
| Crohns disease | |||
| 2 or less prior lines of therapy | 8 | 0 | .0047 |
| 3 or more prior lines of therapy | 4 | 8 | |
| Median BSA | 1.98 (1.65-2.39) | 1.70 (1.48-2.29) | .1878 |
| Median weight, kg | 80.(61-114) | 67 (48-105) | .2779 |
| Splenectomy, prior | 1 | 1 | |
| Platelets | |||
| Baseline, median ×109/L | 18.5 (4-35) | 16.0 (4-24) | .2114 |
| Day 7, median | 109.0 (1-322) | 45.0 (9-114) | .0861 |
| Day 14, median | 91.5 (6-413) | 25 (9-252) | .0566 |
| Day 21, median | 92.5 (14-393) | 27.5 (8-79) | .0051 |
| Day 28, median | 144.5 (22-337) | 18.5 (9-131) | .0021 |
| Day 60, median | 108 (23-316) | 20 (1-61) | .0008 |
| Patients with platelets >30 × 109/L, day 30 | 11 | 3 | .0181 |
| Patients with platelets >30 × 109/L, at day 60 | 11 | 1 | .0017 |