Baseline demographics and disease characteristics
| . | N = 27 . |
|---|---|
| Age (y), median (min, max) | 78.0 (64, 92) |
| Age distribution, n (%) | |
| <65 y | 2 (7) |
| ≥65 and ≤74 y | 8 (30) |
| ≥75 and ≤84 y | 12 (44) |
| ≥85 y | 5 (19) |
| Gender, male, n (%) | 14 (52) |
| ECOG performance status, n (%) | |
| Grade 0/1 | 21 (78) |
| Grade 2/3 | 6 (22) |
| Karnofsky performance status, median (min, max) | 90 (60, 100) |
| Histologic subtype of HL | |
| Nodular sclerosis | 12 (44) |
| Mixed cellularity | 5 (19) |
| Lymphocyte-rich classical HL | 4 (15) |
| Lymphocyte-depleted classical HL | 1 (4) |
| Classical HL NOS | 4 (15) |
| Other (NLPHL)* | 1 (4) |
| Stage at diagnosis, n (%) | |
| Early stage I/II | 10 (37) |
| Late stage III/IV | 17 (63) |
| Percent CD30+ malignant cells, median (min, max) | 90 (20, 100) |
| B symptoms, n (%) | 6 (22) |
| Bulky disease, n (%) | 6 (22) |
| Extra-nodal involvement, n (%) | 14 (52) |
| Renal impairment category,† n (%) | |
| Unimpaired (CrCl >80 mL/min) | 8 (30) |
| Mild (CrCl >50 to ≤80 mL/min) | 7 (26) |
| Moderate (CrCl ≥30 to ≤50 mL/min) | 12 (44) |
| Cardiac ejection fraction, %, median (min, max) | 65 (49, 74) |
| . | N = 27 . |
|---|---|
| Age (y), median (min, max) | 78.0 (64, 92) |
| Age distribution, n (%) | |
| <65 y | 2 (7) |
| ≥65 and ≤74 y | 8 (30) |
| ≥75 and ≤84 y | 12 (44) |
| ≥85 y | 5 (19) |
| Gender, male, n (%) | 14 (52) |
| ECOG performance status, n (%) | |
| Grade 0/1 | 21 (78) |
| Grade 2/3 | 6 (22) |
| Karnofsky performance status, median (min, max) | 90 (60, 100) |
| Histologic subtype of HL | |
| Nodular sclerosis | 12 (44) |
| Mixed cellularity | 5 (19) |
| Lymphocyte-rich classical HL | 4 (15) |
| Lymphocyte-depleted classical HL | 1 (4) |
| Classical HL NOS | 4 (15) |
| Other (NLPHL)* | 1 (4) |
| Stage at diagnosis, n (%) | |
| Early stage I/II | 10 (37) |
| Late stage III/IV | 17 (63) |
| Percent CD30+ malignant cells, median (min, max) | 90 (20, 100) |
| B symptoms, n (%) | 6 (22) |
| Bulky disease, n (%) | 6 (22) |
| Extra-nodal involvement, n (%) | 14 (52) |
| Renal impairment category,† n (%) | |
| Unimpaired (CrCl >80 mL/min) | 8 (30) |
| Mild (CrCl >50 to ≤80 mL/min) | 7 (26) |
| Moderate (CrCl ≥30 to ≤50 mL/min) | 12 (44) |
| Cardiac ejection fraction, %, median (min, max) | 65 (49, 74) |