Table 5

Treatment-emergent AEs occurring in at least 15% of patients treated with frontline brentuximab vedotin monotherapy

N = 27
Event*Grade 1/2 n (%)Grade 3 n (%)Total n (%)
Peripheral sensory neuropathy 14 (52) 7 (26) 21 (78) 
Fatigue 12 (44) 12 (44) 
Nausea 12 (44) 12 (44) 
Peripheral edema 10 (37) 10 (37) 
Diarrhea 9 (33) 9 (33) 
Decreased appetite 8 (30) 8 (30) 
Constipation 7 (26) 7 (26) 
Alopecia 5 (19) 5 (19) 
Cough 5 (19) 5 (19) 
Muscular weakness 5 (19) 5 (19) 
Pruritus 5 (19) 5 (19) 
Rash 3 (11) 2 (7) 5 (19) 
Urinary tract infection 4 (15) 1 (4) 5 (19) 
Vomiting 5 (19) 5 (19) 
Deep vein thrombosis 4 (15) 4 (15) 
Dizziness 4 (15) 4 (15) 
Maculopapular rash 3 (11) 1 (4) 4 (15) 
Weight decreased 4 (15) 4 (15) 
N = 27
Event*Grade 1/2 n (%)Grade 3 n (%)Total n (%)
Peripheral sensory neuropathy 14 (52) 7 (26) 21 (78) 
Fatigue 12 (44) 12 (44) 
Nausea 12 (44) 12 (44) 
Peripheral edema 10 (37) 10 (37) 
Diarrhea 9 (33) 9 (33) 
Decreased appetite 8 (30) 8 (30) 
Constipation 7 (26) 7 (26) 
Alopecia 5 (19) 5 (19) 
Cough 5 (19) 5 (19) 
Muscular weakness 5 (19) 5 (19) 
Pruritus 5 (19) 5 (19) 
Rash 3 (11) 2 (7) 5 (19) 
Urinary tract infection 4 (15) 1 (4) 5 (19) 
Vomiting 5 (19) 5 (19) 
Deep vein thrombosis 4 (15) 4 (15) 
Dizziness 4 (15) 4 (15) 
Maculopapular rash 3 (11) 1 (4) 4 (15) 
Weight decreased 4 (15) 4 (15) 
*

AEs were summarized using MedDRA version 15.1 and graded using the NIH National Cancer Institute Common Terminology Criteria for Adverse Events version 4.03.

No grade 4 events were reported for these AE terms.

or Create an Account

Close Modal
Close Modal