Full blood examination of RBC10 mice
| . | +/+ . | RBC10+/m . | RBC10m/m . |
|---|---|---|---|
| Hemoglobin (g/dL) | 16.66 ± 0.51 | 15.87 ± 0.39* | 15.33 ± 0.55* |
| Red cells (×1012/L) | 11.17 ± 0.32 | 12.31 ± 0.47* | 13.61 ± 0.40*† |
| Hematocrit (%) | 49.71 ± 0.95 | 48.23 ± 1.59* | 47.51 ± 1.96*† |
| MCV (fl) | 44.52 ± 0.84 | 39.20 ± 0.67* | 34.91 ± 0.92*† |
| MCH (pg) | 14.90 ± 0.56 | 12.91 ± 0.37* | 11.26 ± 0.33*† |
| MCHC (g/dL) | 33.45 ± 0.81 | 32.95 ± 0.80 | 32.31 ± 1.01 |
| RDW (%) | 15.97 ± 1.81 | 18.05 ± 1.20* | 19.45 ± 0.89*† |
| Reticulocytes (%) | 2.68 ± 0.53 | 2.74 ± 0.60 | 3.0 ± 0.50 |
| Platelets (×109/L) | 1007 ± 98 | 1020 ± 116 | 1113 ± 119 |
| White cells (×109/L) | 8.48 ± 1.38 | 8.23 ± 2.27 | 10.36 ± 3.02 |
| Ferritin (μg/L) | 1815 ± 191 | ND | 1560 ± 175 |
| . | +/+ . | RBC10+/m . | RBC10m/m . |
|---|---|---|---|
| Hemoglobin (g/dL) | 16.66 ± 0.51 | 15.87 ± 0.39* | 15.33 ± 0.55* |
| Red cells (×1012/L) | 11.17 ± 0.32 | 12.31 ± 0.47* | 13.61 ± 0.40*† |
| Hematocrit (%) | 49.71 ± 0.95 | 48.23 ± 1.59* | 47.51 ± 1.96*† |
| MCV (fl) | 44.52 ± 0.84 | 39.20 ± 0.67* | 34.91 ± 0.92*† |
| MCH (pg) | 14.90 ± 0.56 | 12.91 ± 0.37* | 11.26 ± 0.33*† |
| MCHC (g/dL) | 33.45 ± 0.81 | 32.95 ± 0.80 | 32.31 ± 1.01 |
| RDW (%) | 15.97 ± 1.81 | 18.05 ± 1.20* | 19.45 ± 0.89*† |
| Reticulocytes (%) | 2.68 ± 0.53 | 2.74 ± 0.60 | 3.0 ± 0.50 |
| Platelets (×109/L) | 1007 ± 98 | 1020 ± 116 | 1113 ± 119 |
| White cells (×109/L) | 8.48 ± 1.38 | 8.23 ± 2.27 | 10.36 ± 3.02 |
| Ferritin (μg/L) | 1815 ± 191 | ND | 1560 ± 175 |
Blood parameters obtained from 7-week-old male wild-type (+/+, n = 12), RBC10 heterozygous (n = 19), and RBC10 homozygous (n = 11) mice. Means ± SDs are shown. MCHC, mean corpuscular hemoglobin concentration; ND, not done; RDW, red cell distribution width.
P < .05 compared with WT mice, two-tailed Student t test.
P < 0.05 compared with RBC10+/m mice, two-tailed Student t test.