Genotypes of 10-day-old offspring
| . | Sickle genotype . | |||||
|---|---|---|---|---|---|---|
| AA . | AA . | AS . | AS . | SS . | SS . | |
| Kcc1 genotype | +/M | M/M | +/M | M/M | +/M | M/M |
| Expected % | 12.5 | 12.5 | 25 | 25 | 12.5 | 12.5 |
| Observed n (%) | 13 (19%) | 13 (19%) | 13 (19%) | 17 (25%) | 10 (15%) | 3 (4%)* |
| . | Sickle genotype . | |||||
|---|---|---|---|---|---|---|
| AA . | AA . | AS . | AS . | SS . | SS . | |
| Kcc1 genotype | +/M | M/M | +/M | M/M | +/M | M/M |
| Expected % | 12.5 | 12.5 | 25 | 25 | 12.5 | 12.5 |
| Observed n (%) | 13 (19%) | 13 (19%) | 13 (19%) | 17 (25%) | 10 (15%) | 3 (4%)* |
Offspring generated by mating HbAS Kcc1+/M935K mice with HbAS Kcc1M935K/M935K mice.
χ2 test: P = .001.