Table 4 Comparison of previously... | American Society of Hematology

Table 4

Comparison of previously identified VTE risk alleles between the discovery cohort and populations of EA

			Discovery cohort			Previous studies
Chr	SNP	Allele	AF	OR (95% CI)	P*	AF	OR	P	Reference
1	rs6025 (F5)	T	0.0	NA	NA	0.06	2.56	1.40 × 10⁻¹²	11
11	rs1799963 (F2)	A	0.0	NA	NA	0.02	1.69	3.00 × 10⁻²	11
9	rs687621 (ABO)	G	0.43	1.55 (1.2-2.0)	0.002	0.43	1.84	6.69 × 10⁻²²	10
9	rs505922 (ABO)	C	0.36	1.52 (1.2-2.0)	0.002	0.43	1.85	1.84 × 10⁻²²	10
9	rs657152 (ABO)	A	0.44	1.39 (1.1-1.8)	0.03	0.45	1.7	2.00 × 10⁻¹⁷	10
10	rs78707713 (TSPAN15)	T	0.97†	NA	NA	0.88	1.28	5.74 × 10⁻¹¹	29
19	rs2288904 (SLC44A2)	G	0.93	0.90 (0.5-1.5)	0.75	0.79	1.19	1.07 × 10⁻⁹	29

			Discovery cohort			Previous studies
Chr	SNP	Allele	AF	OR (95% CI)	P*	AF	OR	P	Reference
1	rs6025 (F5)	T	0.0	NA	NA	0.06	2.56	1.40 × 10⁻¹²	11
11	rs1799963 (F2)	A	0.0	NA	NA	0.02	1.69	3.00 × 10⁻²	11
9	rs687621 (ABO)	G	0.43	1.55 (1.2-2.0)	0.002	0.43	1.84	6.69 × 10⁻²²	10
9	rs505922 (ABO)	C	0.36	1.52 (1.2-2.0)	0.002	0.43	1.85	1.84 × 10⁻²²	10
9	rs657152 (ABO)	A	0.44	1.39 (1.1-1.8)	0.03	0.45	1.7	2.00 × 10⁻¹⁷	10
10	rs78707713 (TSPAN15)	T	0.97†	NA	NA	0.88	1.28	5.74 × 10⁻¹¹	29
19	rs2288904 (SLC44A2)	G	0.93	0.90 (0.5-1.5)	0.75	0.79	1.19	1.07 × 10⁻⁹	29

AF, allele frequency; Chr, chromosome; NA, not available.

Age adjusted.

Allele frequency taken from 1000 Genomes–Americans of African Ancestry in SW USA (ASW).