Frequency of CNS engraftment in primary patient samples
| Cytogenetic subgroup . | Sample identifier . | CNS status at diagnosis (cytospin) . | Mice with CNS engraftment, n/N . |
|---|---|---|---|
| t(12;21) | #4630 | CNS-1 | 0/3 |
| #4736 | CNS-1 | 2/2 | |
| #5449 | CNS-1 | 1/2 | |
| #5094 | CNS-3 | 3/3 | |
| #6112 | CNS-1 | 1/2 | |
| #5705 | CNS-1 | 2/2 | |
| High hyperdiploid | #L779 | CNS-1 | 5/5 |
| #5969 | CNS-1 | 0/2 | |
| #6294 | CNS-1 | 0/1 | |
| t(7;9)dic(9;20) | #21819 | CNS-1 | 1/1 |
| t(9;22) | #4540 | TLP+ | 2/2 |
| #M120 | TLP− | 2/2 | |
| #WB51 | CNS-1 | 7/7 | |
| t(9;22), del 9p | #HV101 | TLP+ | 2/2 |
| Bcr-abl-like | #737c | CNS-1 | 12/13 |
| #758b | CNS-1 | 3/5 | |
| t(11q23) | #6240 | CNS-3 | 3/3 |
| #5655 | CNS-1 | 3/3 | |
| #4861 | CNS-1 | 0/2 | |
| t(1;19) | #L910 | CNS-1 | 1/1 |
| #BH01 | CNS-1 | 0/3 | |
| t(8;14) non-Burkitt | #20580 | CNS-1 | 4/5 |
| iAmp21 | #L868 | CNS-1 | 7/7 |
| #L904 | CNS-1 | 0/2 | |
| t(17;19) | #L707 | CNS-1 | 2/2 |
| Immunoglobulin H translocation | #20951 | CNS-1 | 3/3 |
| CRLF2 deletion | #11538 | CNS-1 | 4/4 |
| No result | #L897 | CNS-1 | 4/4 |
| #L920 | CNS-1 | 1/1 | |
| Totals | |||
| 13 Cytogenetic groups | 29 Patient samples | 2 CNS-3, 24 CNS-1, 3 TLP | 75/94 Mice and 23/29 primary samples engrafted in CNS |
| Cytogenetic subgroup . | Sample identifier . | CNS status at diagnosis (cytospin) . | Mice with CNS engraftment, n/N . |
|---|---|---|---|
| t(12;21) | #4630 | CNS-1 | 0/3 |
| #4736 | CNS-1 | 2/2 | |
| #5449 | CNS-1 | 1/2 | |
| #5094 | CNS-3 | 3/3 | |
| #6112 | CNS-1 | 1/2 | |
| #5705 | CNS-1 | 2/2 | |
| High hyperdiploid | #L779 | CNS-1 | 5/5 |
| #5969 | CNS-1 | 0/2 | |
| #6294 | CNS-1 | 0/1 | |
| t(7;9)dic(9;20) | #21819 | CNS-1 | 1/1 |
| t(9;22) | #4540 | TLP+ | 2/2 |
| #M120 | TLP− | 2/2 | |
| #WB51 | CNS-1 | 7/7 | |
| t(9;22), del 9p | #HV101 | TLP+ | 2/2 |
| Bcr-abl-like | #737c | CNS-1 | 12/13 |
| #758b | CNS-1 | 3/5 | |
| t(11q23) | #6240 | CNS-3 | 3/3 |
| #5655 | CNS-1 | 3/3 | |
| #4861 | CNS-1 | 0/2 | |
| t(1;19) | #L910 | CNS-1 | 1/1 |
| #BH01 | CNS-1 | 0/3 | |
| t(8;14) non-Burkitt | #20580 | CNS-1 | 4/5 |
| iAmp21 | #L868 | CNS-1 | 7/7 |
| #L904 | CNS-1 | 0/2 | |
| t(17;19) | #L707 | CNS-1 | 2/2 |
| Immunoglobulin H translocation | #20951 | CNS-1 | 3/3 |
| CRLF2 deletion | #11538 | CNS-1 | 4/4 |
| No result | #L897 | CNS-1 | 4/4 |
| #L920 | CNS-1 | 1/1 | |
| Totals | |||
| 13 Cytogenetic groups | 29 Patient samples | 2 CNS-3, 24 CNS-1, 3 TLP | 75/94 Mice and 23/29 primary samples engrafted in CNS |
Samples are grouped by cytogenetics. CNS engraftment was determined histologically and analyzed blinded to patient details.
TLP, traumatic lumbar puncture with visible leukemic blasts (+) or without (−).