Table 1 Characteristics of anti-A2 MAbs... | American Society of Hematology

Table 1

Characteristics of anti-A2 MAbs

Name	Domain	Group	Epitope	BU/mg IgG	BU/mL plasma*	Type
2-76	A2	A	Arg484-Ile508	38 000	190	I
4A4	A2	A	Asp403-His444	40 000	200	I
B94	A2	B	Arg541-Glu604	Indeterminate†	Indeterminate	II
B25	A2	C	His444-Gln468	100	<1	I
2-54	A2	D	Glu604-Arg740	34 000	170	II
GMA-012	A2	D	Glu604-Arg740	<1	<1	N/A
4C7	A2	E	Unknown	<1	<1	N/A
1D4	A2	E	Glu604-Arg740	7,000	35	I

Name	Domain	Group	Epitope	BU/mg IgG	BU/mL plasma*	Type
2-76	A2	A	Arg484-Ile508	38 000	190	I
4A4	A2	A	Asp403-His444	40 000	200	I
B94	A2	B	Arg541-Glu604	Indeterminate†	Indeterminate	II
B25	A2	C	His444-Gln468	100	<1	I
2-54	A2	D	Glu604-Arg740	34 000	170	II
GMA-012	A2	D	Glu604-Arg740	<1	<1	N/A
4C7	A2	E	Unknown	<1	<1	N/A
1D4	A2	E	Glu604-Arg740	7,000	35	I

Calculated using estimated plasma volume and antibody concentration.

Residual fVIII activity at saturating concentrations of MAb was higher than 50%.