Safety profile of induction therapy with VTD or VCD
| . | VTD (n = 169) grade 3-4 (%) . | VCD (n = 169) grade 3-4 (%) . | P value . |
|---|---|---|---|
| Any AEs | 63.9 | 68.2 | .40 |
| Anemia | 4.1 | 9.5 | .05 |
| Neutropenia | 18.9 | 33.1 | .003 |
| Infection | 7.7 | 10.1 | .45 |
| Thrombocytopenia | 4.7 | 10.6 | .04 |
| Thrombosis | 1.8 | 1.8 | .99 |
| Cardiac disorders | 1.2 | 0 | .16 |
| Cystitis | 0 | 0.6 | .32 |
| Gastrointestinal symptoms | 5.3 | 3.5 | .42 |
| PN | 7.7 | 2.9 | .05 |
| PN grade 2 - 4 | 21.9 | 12.9 | .008 |
| . | VTD (n = 169) grade 3-4 (%) . | VCD (n = 169) grade 3-4 (%) . | P value . |
|---|---|---|---|
| Any AEs | 63.9 | 68.2 | .40 |
| Anemia | 4.1 | 9.5 | .05 |
| Neutropenia | 18.9 | 33.1 | .003 |
| Infection | 7.7 | 10.1 | .45 |
| Thrombocytopenia | 4.7 | 10.6 | .04 |
| Thrombosis | 1.8 | 1.8 | .99 |
| Cardiac disorders | 1.2 | 0 | .16 |
| Cystitis | 0 | 0.6 | .32 |
| Gastrointestinal symptoms | 5.3 | 3.5 | .42 |
| PN | 7.7 | 2.9 | .05 |
| PN grade 2 - 4 | 21.9 | 12.9 | .008 |