VWF, ADAMTS13, and markers of thrombin generation in patients with STEMI
| Parameter . | . | Peripheral venous blood . | Coronary blood, pre-occlusion . | Coronary blood, post-occlusion . | P* . | |||
|---|---|---|---|---|---|---|---|---|
| Unit . | Median . | IQR . | Median . | IQR . | Median . | IQR . | ||
| VWF:RCo | % | 184 | 114-277 | 190 | 124-263 | 146† | 106-236 | .003 |
| VWF:Ag | % | 167 | 115-248 | 157 | 119-207 | 137† | 99-192 | <.001 |
| VWF:RCo/VWF:Ag | Ratio | 1.06 | 0.95-1.23 | 1.13 | 0.97-1.34 | 1.10 | 0.99-1.30 | .540 |
| ADAMTS13 | % | 75 | 67-85 | 53‡ | 31-75 | 48‡ | 39-68 | <.001 |
| ADAMTS13/VWF:RCo | Ratio | 0.48 | 0.24-0.65 | 0.31‡ | 0.15-0.46 | 0.29‡ | 0.19-0.49 | <.001 |
| F1+2 | pmol/mL | 177 | 106-280 | 135 | 105-264 | 159 | 117-237 | .190 |
| TAT | ng/mL | 5.9 | 3.4-12.4 | 4.3 | 2.9-6.7 | 5.1 | 3.9-9.6 | .065 |
| D-dimers | ng/mL | 397 | 194-665 | 393 | 219-963 | 417 | 239-1097 | .468 |
| Parameter . | . | Peripheral venous blood . | Coronary blood, pre-occlusion . | Coronary blood, post-occlusion . | P* . | |||
|---|---|---|---|---|---|---|---|---|
| Unit . | Median . | IQR . | Median . | IQR . | Median . | IQR . | ||
| VWF:RCo | % | 184 | 114-277 | 190 | 124-263 | 146† | 106-236 | .003 |
| VWF:Ag | % | 167 | 115-248 | 157 | 119-207 | 137† | 99-192 | <.001 |
| VWF:RCo/VWF:Ag | Ratio | 1.06 | 0.95-1.23 | 1.13 | 0.97-1.34 | 1.10 | 0.99-1.30 | .540 |
| ADAMTS13 | % | 75 | 67-85 | 53‡ | 31-75 | 48‡ | 39-68 | <.001 |
| ADAMTS13/VWF:RCo | Ratio | 0.48 | 0.24-0.65 | 0.31‡ | 0.15-0.46 | 0.29‡ | 0.19-0.49 | <.001 |
| F1+2 | pmol/mL | 177 | 106-280 | 135 | 105-264 | 159 | 117-237 | .190 |
| TAT | ng/mL | 5.9 | 3.4-12.4 | 4.3 | 2.9-6.7 | 5.1 | 3.9-9.6 | .065 |
| D-dimers | ng/mL | 397 | 194-665 | 393 | 219-963 | 417 | 239-1097 | .468 |
VWF:RCo, VWF ristocetin cofactor activity.
Statistical analysis by Friedman repeated measures analysis of variance on ranks, all pairwise comparison procedure (Tukey test), n = 27.
Statistically significantly different from peripheral blood and pre-occlusion coronary blood.
Statistically significantly different from peripheral blood.