Table 1 KIR-KIRL combinations that... | American Society of Hematology

Table 1

KIR-KIRL combinations that effectively contribute to NK cell alloreactivity

KIR-KIRL interaction	Functional consequences	NK cell alloreactivity toward
KIR2DL1–HLA-C2	Inhibition in HLA-C2⁺ patients	Lysis in HLA-C1⁺ patients
KIR2DL2/3–HLA-C1	inhibition in HLA-C1⁺ patients	Partial lysis in HLA-C2⁺ patients*
KIR3DL1–HLA-Bw4	Inhibition in patients with Bw4⁺ supertypic specificity	Lysis in Bw4⁻ patients
KIR2DS1–HLA-C2	Activation in HLA-C2⁺ patients	Lysis in HLA-C2⁺ patients (only when donor is HLA-C1/C1)

KIR-KIRL interaction	Functional consequences	NK cell alloreactivity toward
KIR2DL1–HLA-C2	Inhibition in HLA-C2⁺ patients	Lysis in HLA-C1⁺ patients
KIR2DL2/3–HLA-C1	inhibition in HLA-C1⁺ patients	Partial lysis in HLA-C2⁺ patients*
KIR3DL1–HLA-Bw4	Inhibition in patients with Bw4⁺ supertypic specificity	Lysis in Bw4⁻ patients
KIR2DS1–HLA-C2	Activation in HLA-C2⁺ patients	Lysis in HLA-C2⁺ patients (only when donor is HLA-C1/C1)

See Pende et al.⁴⁰