Soluble biomarkers before and after rhIL-7 treatment
| Biomarker . | HCs (n = 31) . | Study patients (n = 9) . | P . | ||||
|---|---|---|---|---|---|---|---|
| Week 1 . | Week 12 . | Week 24 . | HCs vs Week 1 . | Week 12 vs Week 1 . | Week 24 vs Week 1 . | ||
| IL-7 (pg/mL) | 8.62 | 12.70 | 17.69 | 20.33 | <.0001 | NS | NS |
| IL-6 (pg/mL) | 1.37 | 1.570 | 1.420 | 1.000 | NS | NS | NS |
| TNF (pg/mL) | 3.55 | 3.35 | 3.760 | 3.720 | NS | .020 | .055 |
| Eotaxin-3 (pg/mL) | 6.27 | 5.580 | 6.040 | 5.490 | NS | NS | NS |
| SDF-1 (pg/mL) | 2032 | 1813 | 1522 | 1666 | .0004 | NS | NS |
| d-dimer (mg/L) | 0.285 | 0.435 | 0.618 | 0.761 | NS | NS | NS |
| Neopterin (nmol/L) | 5.780 | 4.080 | 4.260 | 3.010 | .016 | NS | .039 |
| CRP (mg/L) | 1.700 | 2.170 | 1.488 | 1.411 | NS | NS | NS |
| sCD14 (μg/mL) | 1.214 | 1.447 | 1.372 | 1.526 | NS | NS | NS |
| sCD163 (pg/mL) | 365.8 | 153.0 | 336.9 | 281.9 | .205 | .027 | NS |
| Biomarker . | HCs (n = 31) . | Study patients (n = 9) . | P . | ||||
|---|---|---|---|---|---|---|---|
| Week 1 . | Week 12 . | Week 24 . | HCs vs Week 1 . | Week 12 vs Week 1 . | Week 24 vs Week 1 . | ||
| IL-7 (pg/mL) | 8.62 | 12.70 | 17.69 | 20.33 | <.0001 | NS | NS |
| IL-6 (pg/mL) | 1.37 | 1.570 | 1.420 | 1.000 | NS | NS | NS |
| TNF (pg/mL) | 3.55 | 3.35 | 3.760 | 3.720 | NS | .020 | .055 |
| Eotaxin-3 (pg/mL) | 6.27 | 5.580 | 6.040 | 5.490 | NS | NS | NS |
| SDF-1 (pg/mL) | 2032 | 1813 | 1522 | 1666 | .0004 | NS | NS |
| d-dimer (mg/L) | 0.285 | 0.435 | 0.618 | 0.761 | NS | NS | NS |
| Neopterin (nmol/L) | 5.780 | 4.080 | 4.260 | 3.010 | .016 | NS | .039 |
| CRP (mg/L) | 1.700 | 2.170 | 1.488 | 1.411 | NS | NS | NS |
| sCD14 (μg/mL) | 1.214 | 1.447 | 1.372 | 1.526 | NS | NS | NS |
| sCD163 (pg/mL) | 365.8 | 153.0 | 336.9 | 281.9 | .205 | .027 | NS |
CRP, C-reactive protein; NS, not significant.